Skin cancers in chronic arsenic toxicity--a study of predictive value of some proliferative markers.

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dc.contributor.authorPaul, Prabir Chandraen_US
dc.contributor.authorChattopadhyay, Amitabhaen_US
dc.contributor.authorManna, A Ken_US
dc.contributor.authorDutta, S Ken_US
dc.date.accessioned2004-04-22en_US
dc.date.accessioned2009-05-29T12:05:52Z
dc.date.available2004-04-22en_US
dc.date.available2009-05-29T12:05:52Z
dc.date.issued2004-04-22en_US
dc.description.abstractProlonged exposure to arsenic contaminated water produces various clinical features, cutaneous features e.g. melanosis, keratosis and cancers being very common. Evaluation of such lesions by proliferative markers can provide useful information in regards to the biological behaviour of the lesions. Thus, cases with high proliferative status can be ominous sign for development of cancers. We studied skin biopsy of 42 cases. These were evaluated with AgNOR score and PCNA stain, in addition to H & E examination. Here, invasive cancer cases had mean AgNOR score of 3.56, those with severe dysplasia had 3.0, moderate and mild dysplasia scored 1.73, benign changes had mean score of 1.35 while normal control cases had 1.08. PCNA index in cancers was above 50, that of severe dysplasia 25-30, mild to moderate dysplasia 1.0-5.0, those with benign changes 0.5 -1.0 and normal control had LI of less than 0.5%. PCNA has the advantage of less chance of observer error over AgNOR stain.en_US
dc.description.affiliationDepartment of Pathology, University College of Medicine, Kolkata. prabirchpaul@yahoo.comen_US
dc.identifier.citationPaul PC, Chattopadhyay A, Manna AK, Dutta SK. Skin cancers in chronic arsenic toxicity--a study of predictive value of some proliferative markers. Indian Journal of Pathology & Microbiology. 2004 Apr; 47(2): 206-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74226
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshArsenic --toxicityen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshSkin Neoplasms --chemically induceden_US
dc.subject.meshStaining and Labelingen_US
dc.subject.meshTumor Markers, Biologicalen_US
dc.titleSkin cancers in chronic arsenic toxicity--a study of predictive value of some proliferative markers.en_US
dc.typeJournal Articleen_US
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