Safety assessment of hydroethanolic rambutan rind extract: Acute and sub-chronic toxicity studies.

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dc.contributor.authorThinkratok, Aree
dc.contributor.authorSuwannaprapha, Parin
dc.contributor.authorSrisawat, Rungrudee
dc.date.accessioned2014-12-12T10:39:41Z
dc.date.available2014-12-12T10:39:41Z
dc.date.issued2014-10
dc.description.abstractThis study evaluated the safety of rambutan rind extract (RRE) in male Wistar rats. While acute toxicity was evaluated by feeding the rats with single doses of RRE (1000, 2000, 3000, 4000, and 5000 mg/kg) and its sub-chronic toxicity was observed in rats orally administered with RRE (500, 1000, and 2000 mg/kg) daily for 30 days. In acute toxicity study, the LD50 was found to be greater than 5000 mg/kg of RRE. In sub-chronic toxicity study, no mortality and sign of toxicity was found up to 1000 mg/kg/day of RRE. At 2000 mg/kg/day dose, the mortality rate was 12.5%. Significant decreases in body weight gain and food consumption were found in both acute and sub-chronic toxicity studies. In acute toxicity study, all the studied doses of RRE did not alter serum levels of triglyceride (TG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT). In sub-chronic toxicity study, all studied doses of RRE significantly decreased plasma levels of TG and blood urea nitrogen, but did not alter plasma levels of AST and ALT. TC levels did not show any significant change in both the studies. The obtained results provide basic information for in vivo experimental studies of the pharmacological potentiality of RRE.en_US
dc.identifier.citationThinkratok Aree, Suwannaprapha Parin, Srisawat Rungrudee. Safety assessment of hydroethanolic rambutan rind extract: Acute and sub-chronic toxicity studies. Indian Journal of Experimental Biology. 2014 Oct; 52(10): 989-995.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153793
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/29443en_US
dc.subjectAcute toxicityen_US
dc.subjectNephelium lappaceumen_US
dc.subjectRambutanen_US
dc.subjectSub-chronic toxicityen_US
dc.subject.meshAnimals
dc.subject.meshBlood Glucose --drug effects
dc.subject.meshBody Weight --drug effects
dc.subject.meshEating --drug effects
dc.subject.meshMale
dc.subject.meshPlant Extracts --toxicity
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshSapindaceae --chemistry
dc.subject.meshToxicity Tests, Acute
dc.subject.meshToxicity Tests, Subchronic
dc.titleSafety assessment of hydroethanolic rambutan rind extract: Acute and sub-chronic toxicity studies.en_US
dc.typeArticleen_US
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