Association of Serum Uric Acid with Preeclampsia: A Case Control Study.
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Date
2013-07
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Abstract
Background: Preeclampsia (PE) is still one of the important causes of maternal and fetal mortality in
Bangladesh. Many researches have been done to identify a unique screening test that would predict the risk of
developing PE before the classic symptoms appear. One of the most accessible and easiest screening tests is serum
uric acid measurement. Numerous studies have demonstrated a relation between elevated maternal serum uric
acid levels and adverse maternal and fetal outcome. Among several pathophysiologic factors the most commonly
accepted explanation for hyperuricemia in PE is increased reabsorption and decreased excretion of uric acid.
Objective: The aim of the present study was to assess the association of serum uric acid with preeclampsia.
Materials and method: A case control study was conducted in the department of Biochemistry, Dhaka Medical
College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in third trimester of
pregnancy attending in Obstetrics and Gynaecology department of Dhaka Medical College Hospital were selected
purposively as study subjects. Among them 50 pregnant women with preeclampsia were selected as cases and 50
normal healthy pregnant women as controls. Results: Most of the study subjects were within 21 – 30 years of age
group and mean age in case and control was 24.06±3.71 and 24.66±3.22 years respectively, which was not
statistically different. Mean gestational age in case and control was 33.50±2.55 weeks and 33.60±2.95 weeks
respectively, which was also not statistically different. Among the study subjects majority was primi in both groups
(case 76%, contol 58%) showing no statistical significance. Majority of the subjects in both groups were irregular
in their antenatal checkup (case 52%, contol 40%). Uric acid concentration was measured in all the study
subjects. The mean serum uric acid concentration in cases and controls were 7.01±1.90 mg/dl and 4.55±1.63
mg/dl respectively. This difference was highly significant in statistical point of view. Conclusion: Hyperuricemia
is associated with preeclampsia.
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Keywords
Preeclampsia, uric acid
Citation
Sultana Razia, Ahmed Selina, Sultana Nasima, Karim S.M. Fazlul, Atia Farhana. Association of Serum Uric Acid with Preeclampsia: A Case Control Study. Delta Medical College Journal. 2013 July; 1(2): 46-50.