Clinical Profile of Dengue Haemorrhagic Fever from Jan 2009 to Dec 2009 in and Around Aurangabad.
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2011-06
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Abstract
In present study 890 serum samples suspected of dengue fever on clinical
grounds were received in department of Microbiology. Out of these 249
cases showed thrombocytopenia (platelet coun <1 lakh /cumm) and were
subjected to rapid dengue serological test as well as IgM capture ELISA.
11(4%) cases were diagnosed as primary dengue infection (only IgM
positive) by rapid dengue IgG/IgM bispot immunocomb test. There were
123(49%) cases with only IgG positive suggesting secondary/past dengue
infection. Both IgM and IgG were seen in 24(10%) cases. Number of cases
negative for both IgM and IgG were 91(37%). IgM positive cases were
confirmed by IgM capture ELISA. Classical dengue fever (DF) was
noted in 168 (67%) patients and dengue hemorrhagic fever (DHF) in
81(33%) cases. Common clinical presentations of DHF were fever
78(96%), body-ache 74(91%), arthralgia 74 (91%), retro-orbital pain
65(80%), abdominal pain 07(09%). Bleeding manifestation were in the
form of petechiae, melena, epistaxis, hematuria, hemoptysis,
hematemesis, bleeding gums and conjunctival hemorrhages. Out of 81
DHS patients 13(16%) patients had platelet count between 50,000 and 1
lakh. 68(84%) patients had platelet count below 50,000. Majority of these
patients 47(58%) had platelet below 20000 and were IgG positive.
Thrombocytopenia correlated well with bleeding manifestations in our
patients. In an epidemic setting if the patients present with fever,
vomiting, musculoskeletal pain and bleeding along with low platelet
count a strong possibility of DHF/ DSS should be kept.
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Duthade M M, Bhakare J K, Damle A S. Clinical Profile of Dengue Haemorrhagic Fever from Jan 2009 to Dec 2009 in and Around Aurangabad. Journal of Communicable Diseases. 2011 Jun; 43(2): 131-134.