The growth stimulating factor in parabiotic rats
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Date
1989-04-01
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Abstract
Littermate Wistar rats were parabiosed at 30 days and daily individual food intake and individual weight gain of fifteen parabiotic pairs were recorded as control parabiotic pairs. Another fifteen pairs were used for the experiment in which one partner of parabiotic pair was completely fasted for 4 days and then refed ad libitum till body weight returned to the prefasting level and throughout the experiment, individual body weight changes and individual food intake of both partners of test parabiotic pairs were recorded. During fasting period, daily food intake and weight gain of non-fasted partner of test parabiotic pair increased significantly over that of the individual rat in control parabiotic pair. Moreover, weitht loss of fasted partner is same as that of individual fasted rat. The above findings indicated the presence of factor/factors in plasma of fasted partner stimulating food intake and growth of non-fasted partner of the test parabiotic pair. The present study also reveals that there is greater body weight increase per. g. food consumed (food conversion efficiency) of fasted partner during refeeding period whereas that of non-fasted partner decreased significantly during that period. Food intake and factors controlling it have been extensively studied by Physiologists and Nutritionists interested in growth and its regulation. Various extenal and endogenous stimuli initiate and terminate feeding. Of the endogenous stimuli humoral factors and their mode of action are the subjects of several recent studies (1,3,4,6). The present study is undertaken in order to further clarify and assess the role of humoral factor in the regulation of food intake and growth.
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Maung Maung Cho, San Aung, Myo Thein. The growth stimulating factor in parabiotic rats. Burma Health Sciences Research Journal. 1989; 1(1): 9-14