Correlation of interleukin-33 with Th cytokines and clinical severity of dry eye disease

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dc.contributor.authorLuo, Gen_US
dc.contributor.authorXin, Yen_US
dc.contributor.authorQin, Den_US
dc.contributor.authorYan, Aen_US
dc.contributor.authorZhou, Zen_US
dc.contributor.authorLiu, Zen_US
dc.date.accessioned2020-04-10T01:58:03Z
dc.date.available2020-04-10T01:58:03Z
dc.date.issued2018-01
dc.description.abstractPurpose: The purpose of this study is to determine the tear and serum protein levels of interleukin-33 (IL-33) and its correlation with Th cytokines and disease severity in dry eye (DE) syndrome. Methods: Tear and serum samples were collected from 30 healthy volunteers, 30 DE patients with non-Sjogren's syndrome DE (NSSDE) and 30 DE patients with primary SSDE. The eight most frequent symptoms of DE were scored. All patients underwent corneal and conjunctival staining, tear film breakup time (TBUT), and Schirmer I test. The serum and tear levels of IL-33 were measured by enzyme-linked immunosorbent assay. The levels of IL-33 expression and its correlation with Th cytokines and disease severity were also analyzed. Results: We found that symptom scores and corneal staining grade were significantly higher in SSDE group compared with NSSDE and control group, whereas the results of TBUT and Schirmer I test were significantly lower in SSDE group compared with NSSDE and control group. The tear levels of IL-33 were significantly increased in tears of SSDE patients compared with those of controls and NSSDE patients (P < 0.05). Moreover, the elevated tear levels of IL-33 were positively correlated with symptom scores but negatively correlated with tear film breakup time and Schirmer I test in both NSSDE and SSDE patients (P < 0.05). The tear levels of IL-33 of both NSSDE and SSDE patients were also positively correlated with tear levels of IL-4 and IL-5 (P < 0.05). Correlation between the serum levels of IL-33 with Th1/17/Treg cytokines was not found. Conclusion: Elevated tear levels of IL-33 were associated with the Th2 cytokines and disease severity of DE. Therefore, IL-33 may have important roles in the immunopathogenesis of the DE.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, Yichang Traditional Chinese Medicine Hospital, College of Traditional Chinese Medicine, Three Gorges University, Yichang, Hubei, Chinaen_US
dc.identifier.affiliationsDepartment of Otolaryngology, Renhe Hospital from Three Gorges University, The Second Clinical Hospital of Three Gorges University, Yichang, Hubei, Chinaen_US
dc.identifier.citationLuo G, Xin Y, Qin D, Yan A, Zhou Z, Liu Z. Correlation of interleukin-33 with Th cytokines and clinical severity of dry eye disease. Indian Journal of Ophthalmology. 2018 Jan; 66(1): 39-43en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196578
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume66en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_405_17en_US
dc.subjectDry eyeen_US
dc.subjectinterleukin-33en_US
dc.subjectTh cytokinesen_US
dc.titleCorrelation of interleukin-33 with Th cytokines and clinical severity of dry eye diseaseen_US
dc.typeJournal Articleen_US
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