Metallothionein in male reproductive organs of adrenalectomized and hydrocortisone-treated Wistar rats.

Simple item page
dc.contributor.authorNair, Neenaen_US
dc.contributor.authorBedwal, R Sen_US
dc.date.accessioned2009-05-28T13:15:04Z
dc.date.available2009-05-28T13:15:04Z
dc.date.issued2004-03-06en_US
dc.description.abstractAdrenalectomy resulted in an increase in metallothionein (MT) levels in testes, caput and cauda epididymis and prostate of rats but not in seminal vesicles where its levels decreased significantly. Inspite of administration of hydrocortisone, MT in testes, prostate (1.2 mg), caput (0.3 mg days 2, 8; 0.6 mg and 1.2 mg) and seminal vesicles (0.3 mg day 2, 4; 0.6 mg and 1.2 mg) remained increased. Thus adrenal insufficiency/hydrocortisone has no direct influence on MT levels. However, the increased levels of MT can be related to its ability to protect the cells from free radical damage caused by atrophy of reproductive tissues in adrenalectomised rats. Exogenously administered hydrocortisone to ADX rats resulted in return to ADX state as hydrocortisone metabolizes (half-life < 12 hr) and hence MT levels remained increased. The observations could provide a clue for the physiological functioning of the male reproductive tissue in a state of adrenal deprivation and hormonal supplementation.en_US
dc.description.affiliationCell Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India.en_US
dc.identifier.citationNair N, Bedwal RS. Metallothionein in male reproductive organs of adrenalectomized and hydrocortisone-treated Wistar rats. Indian Journal of Experimental Biology. 2004 Mar; 42(3): 288-91en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59162
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdrenal Glands --physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents --pharmacologyen_US
dc.subject.meshEpididymis --metabolismen_US
dc.subject.meshFree Radicalsen_US
dc.subject.meshHydrocortisone --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMetallothionein --biosynthesisen_US
dc.subject.meshProstate --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSeminal Vesicles --metabolismen_US
dc.subject.meshTestis --metabolismen_US
dc.titleMetallothionein in male reproductive organs of adrenalectomized and hydrocortisone-treated Wistar rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology