Lipid peroxidation and renal injury in renal ischemic reperfusion: effect ofangiotensin inhibition.

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dc.contributor.authorSeujang, Yuyenen_US
dc.contributor.authorKittikowit, Wipaweeen_US
dc.contributor.authorEiam-Ong, Somchaien_US
dc.contributor.authorEiam-Ong, Somchiten_US
dc.date.accessioned2009-05-27T21:46:02Z
dc.date.available2009-05-27T21:46:02Z
dc.date.issued2006-10-30en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVES: To investigate the role of angiotensin inhibition on lipid peroxidation (LPO) and renal pathology in ischemic reperfusion (IR). MATERIAL AND METHOD: Male Wistar rats were subjected to 15-, 30-, 45- or 60- minutes ofrenal ischemia (I) by left renal artery occlusion. In the 30-minute I group, reperfusion (R) for I day (13,R) was performed in additional animals that had been treated with water, angiotensin converting enzyme inhibitor (ACE]; enalapril 5 mg/kg/d), or angiotensin receptor type 1 blocker (ARB; losartan 10 mg/kg/d) one day before I and were continued for 1 day after R. Renal tissue malondialdehyde (MDA), an indicator of LPO, was examined during I and IR periods. Renal pathology was also determined. RESULTS: During ischemia, renal tissue MDA levels were increased throughout the 60-minute ischemic period and was maximum at 30 minutes of ischemia (p < 0.01). Histological changes in 30-minutes I group showed slight tubular cell congestion and mild interstitial edema. One day after reperfusion, MDA levels were still elevated (p < 0. 01) when compared with sham. Progression of renal pathology was observed after I day of reperfusion. Both ACEI and ARB could attenuate the heightened MDA levels (p < 0.01). IR-induced renal injury was markedly diminished by administration ofACEI as well as by ARB. CONCLUSION: These results indicate that inhibition of angiotensin could reduce lipid peroxidation and ameliorate renal injury during IR condition.en_US
dc.description.affiliationDepartment of Physiology, Faculty of Medicine, Chulalongkorn University Bangkok 10330, Thailand.en_US
dc.identifier.citationSeujang Y, Kittikowit W, Eiam-Ong S, Eiam-Ong S. Lipid peroxidation and renal injury in renal ischemic reperfusion: effect ofangiotensin inhibition. Journal of the Medical Association of Thailand. 2006 Oct; 89(10): 1686-93en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45366
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAngiotensin I --antagonists & inhibitorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshKidney --blood supplyen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshReperfusion Injury --prevention & controlen_US
dc.titleLipid peroxidation and renal injury in renal ischemic reperfusion: effect ofangiotensin inhibition.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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