Newer targeted therapies in psoriasis.

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dc.contributor.authorKhandpur, Sujay
dc.contributor.authorBhari, Neetu
dc.date.accessioned2013-07-25T09:55:26Z
dc.date.available2013-07-25T09:55:26Z
dc.date.issued2013-07
dc.description.abstractPsoriasis is a common, chronic, inflammatory skin disease that can have a significant impact on the quality of life of those who are afflicted due to chronicity of the disease and frequent remissions and relapses. Many available systemic therapies, however, are unsuitable for chronic administration due to the risk of cumulative toxicity. Recent advances in the understanding of the pathophysiology of psoriasis have led to the development of new, genetically engineered, targeted therapies for this disease. These include approaches targeting antigen presentation and co-stimulation, T-cell activation and leukocyte adhesion, action on pro-inflammatory mediators, and modulating the cytokine balance. Although only preliminary data are available so far and there is limited data supporting their use, these trials contribute to a further understanding of the disease and will eventually lead to new therapeutic options for psoriasis.en_US
dc.identifier.citationKhandpur Sujay, Bhari Neetu. Newer targeted therapies in psoriasis. Indian Journal of Dermatology, Venereology and Leprology. 2013 July; 79 Suppl(): S47-52.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147531
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2013;volume=79;issue=7;spage=47;epage=52;aulast=Khandpuren_US
dc.subjectPathogenesisen_US
dc.subjectpsoriasisen_US
dc.subjecttargeted therapyen_US
dc.subject.meshAntibodies, Monoclonal, Humanized --therapeutic use
dc.subject.meshAntigen-Presenting Cells --immunology
dc.subject.meshCalcitriol --therapeutic use
dc.subject.meshCytokines --antagonists & inhibitors
dc.subject.meshHumans
dc.subject.meshMolecular Targeted Therapy
dc.subject.meshPsoriasis --drug therapy
dc.subject.meshReceptors, Chemokine --antagonists & inhibitors
dc.subject.meshRecombinant Fusion Proteins --therapeutic use
dc.subject.meshSignal Transduction --drug effects
dc.titleNewer targeted therapies in psoriasis.en_US
dc.typeArticleen_US
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