Effect of acute hypobaric hypoxia on blood pressure and heart rate and its restoration by chlorogenic acid
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Date
2019-01
Journal Title
Journal ISSN
Volume Title
Publisher
SB Publications
Abstract
Increase in altitude is always accompanied with low pressure and lack ofoxygen. In order to replicate high altitude conditions in normal altitudes, hypobarichypoxia model is often studied. Chlorogenic acid is known to have a variety of effects onhealth and is most notably used to reduce blood pressure and weight loss. In the presentstudy, a simple hypobaric condition has been created using a hypobaric chamber in whichvarious pressure points (0.06, 0.05 and 0.04 MPa) has maintained for different timeperiods (1h, 2h and 4h). The study has been simulated in rat model and their physiologicalconditions including systolic blood pressure and heart rate was monitored after exposureof hypobaric pressure at different time periods with or without administration ofchlorogenic acid. Data reveals that a brief exposure to low pressure do not affect thephysiological conditions to a great extent but longer exposures lead to increased bloodpressure and heart rate. However, it was observed that pre-treatment with chlorogenicacid enabled the rats to combat the stress and the physiological parameters were revertednear to the normal conditions. It can be concluded from this study that, chlorogenic acidbeing an antioxidant can help to recover the altered physiological condition induced byhypobaric hypoxia. Further, biochemical studies are required to explore the amelioratingmechanism. The study also provides an idea regarding the physiological changes takingplace in rats due to low pressure.
Description
Keywords
Hypobaric, Hypoxia, High-altitude;Chlorogenic acid, Blood pressure;Heart rate
Citation
Ranjan Alok, Prakash Alok, Patnaik Ranjana. Effect of acute hypobaric hypoxia on blood pressure and heart rate and its restoration by chlorogenic acid. Journal of Biological Engineering Research and Review. 2019 Jan; 6(1): 44-48