Matrix metalloproteinase-1 expression in oral submucous fibrosis: An immunohistochemical study.

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dc.contributor.authorMishra, Gauri
dc.contributor.authorRanganathan, K
dc.date.accessioned2012-07-26T08:54:51Z
dc.date.available2012-07-26T08:54:51Z
dc.date.issued2010-07
dc.description.abstractContext: Oral submucous fibrosis (OSF) is a form of pathological fibrosis affecting the oral mucosa. There is compelling evidence to implicate the habitual chewing of areca nut with the development of OSF. Because collagens are the major structural components of connective tissues, including oral submucosa, the composition of collagen within each tissue needs to be precisely regulated to maintain tissue integrity. Arecoline stimulates fibroblasts to increase the production of collagen by 150%. Aim: As the role of collagenase is implicated in cleaving the collagen under physical conditions, this study was carried out to evaluate the role of collagenase-1 (matrix metalloproteinase [MMP]-1) in a pathologic condition like OSF. Settings and Design: A total of 40 patients were included in the study, comprising of 30 OSF as Group 1 and 10 normal buccal mucosa tissue as Group 2. Materials and Methods: Both the groups were stained for MMP-1 by the immunohistochemical method using the streptavidin HRP-biotin labeling technique. MMP-1 expression intensity in the epithelium and connective tissue was decreased in Group 1 when compared to Group 2. Statistical Analysis Used: Chi-square test of association was used to determine the difference in the expression of MMP-1 between OSF and normal buccal mucosa and among different histological gradings of OSF. Results: The results were statistically significant. However, there was no statistically significant difference between the expression of MMP-1 among different histological grades of OSF in Group 1.en_US
dc.identifier.citationMishra Gauri, Ranganathan K. Matrix metalloproteinase-1 expression in oral submucous fibrosis: An immunohistochemical study. Indian Journal of Dental Research. 2010 Jul-Sept; 21(3): 320-325.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139873
dc.language.isoenen_US
dc.source.urihttps://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=3;spage=320;epage=325;aulast=Mishraen_US
dc.subjectArecanuten_US
dc.subjectmatrix metalloproteinaseen_US
dc.subjectoral submucous fibrosisen_US
dc.subject.meshAdult
dc.subject.meshAreca --adverse effects
dc.subject.meshBacterial Proteins --diagnostic use
dc.subject.meshBiotin --diagnostic use
dc.subject.meshConnective Tissue --enzymology
dc.subject.meshCytoplasm --enzymology
dc.subject.meshEpithelium --enzymology
dc.subject.meshFemale
dc.subject.meshHorseradish Peroxidase --diagnostic use
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMatrix Metalloproteinase 1 --analysis
dc.subject.meshMiddle Aged
dc.subject.meshMouth Mucosa --enzymology
dc.subject.meshOral Submucous Fibrosis --enzymology
dc.subject.meshOral Submucous Fibrosis --pathology
dc.subject.meshYoung Adult
dc.titleMatrix metalloproteinase-1 expression in oral submucous fibrosis: An immunohistochemical study.en_US
dc.typeArticleen_US
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