Frequency of three common mutations of CARD15/NOD2 gene in Iranian IBD patients.

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dc.contributor.authorDerakhshan, Faramarzen_US
dc.contributor.authorNaderi, Nosratollahen_US
dc.contributor.authorFarnood, Almaen_US
dc.contributor.authorFirouzi, Farzaden_US
dc.contributor.authorHabibi, Manijehen_US
dc.contributor.authorRezvany, Mohammad Rezaen_US
dc.contributor.authorJaveri, Arashen_US
dc.contributor.authorBahari, Alien_US
dc.contributor.authorBalaii, Hediehen_US
dc.contributor.authorRad, Mahta Ghaffarzadehen_US
dc.contributor.authorAghazadeh, Rahimen_US
dc.contributor.authorZali, Mohammad Rezaen_US
dc.date.accessioned2008-01-11en_US
dc.date.accessioned2009-05-29T03:08:10Z
dc.date.available2008-01-11en_US
dc.date.available2009-05-29T03:08:10Z
dc.date.issued2008-01-11en_US
dc.description.abstractBACKGROUND: The CARD15/NOD2 gene, located on the pericentromeric region of chromosome 16 (IBD1) has been reported to have an association with IBD, especially Crohn's disease. Three common mutations of CARD15 are variably associated with Crohn's disease in different ethnic groups. We evaluated the frequency of these mutations (R702W, G908R and 1007fsinsC) in Iranian IBD patients and compared it with the healthy control population. METHODS: One hundred patients with ulcerative colitis, 40 patients with Crohn's disease, and 100 sex- and age-matched controls were enrolled from a tertiary center during a one-year period (2005-2006). The three mutations were assessed in DNA of leukocytes by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). RESULTS: The frequency of R702W mutation was significantly higher in Iranian patients with Crohn's disease (p< 0.001; OR 19.21; 95% CI 4.23-87.32) compared to healthy controls. No association was observed between the other mutations and Crohn's disease and none of these mutations was associated with ulcerative colitis. CONCLUSION: The R702W mutation of CARD15 gene was associated with Crohn's disease in the Iranian population.en_US
dc.description.affiliationResearch Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.en_US
dc.identifier.citationDerakhshan F, Naderi N, Farnood A, Firouzi F, Habibi M, Rezvany MR, Javeri A, Bahari A, Balaii H, Rad MG, Aghazadeh R, Zali MR. Frequency of three common mutations of CARD15/NOD2 gene in Iranian IBD patients. Indian Journal of Gastroenterology. 2008 Jan-Feb; 27(1): 8-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64977
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshColitis, Ulcerative --geneticsen_US
dc.subject.meshCrohn Disease --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammatory Bowel Diseases --geneticsen_US
dc.subject.meshIranen_US
dc.subject.meshMaleen_US
dc.subject.meshMutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.titleFrequency of three common mutations of CARD15/NOD2 gene in Iranian IBD patients.en_US
dc.typeJournal Articleen_US
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