Evaluation of a novel decorporation approach to prevent radioactivity uptake by using acidosis in experimental animals.

Simple item page
dc.contributor.authorSaxena, Priyanka
dc.contributor.authorNishad, Dhruv K
dc.contributor.authorSingh, Thakuri
dc.contributor.authorKumar, Amit
dc.contributor.authorKashyap, Ravi
dc.contributor.authorBhatnagar, Aseem
dc.contributor.authorMittal, Gaurav
dc.date.accessioned2014-12-11T10:24:48Z
dc.date.available2014-12-11T10:24:48Z
dc.date.issued2014-08
dc.description.abstractWith an aim to devise a prophylactic and/or therapeutic approach for preventing internalization of radiothallium (201Tl), and more importantly by implication, its chemical analogue radiocesium (137Cs) during any nuclear emergency, different ex vivo and in vivo animal models were created to determine the role of pH in absorption of 201Tl across jejunum/muscle tissue and whole body retention of 201Tl respectively. Movement of Tl+ under simulated pH conditions proved that pH had direct influence on its absorption. Oral intake of acidified water or parenteral administration of lactic acid was able to reduce the body burden of 201Tl by up to 12 and 50% respectively. The results indicate that acidification of gut, within physiological range may be used as an option for decorporation/inhibition of incorporation of radiothallium and radiocesium, particularly in cases of mass casualty.en_US
dc.identifier.citationSaxena Priyanka, Nishad Dhruv K, Singh Thakuri, Kumar Amit, Kashyap Ravi, Bhatnagar Aseem, Mittal Gaurav. Evaluation of a novel decorporation approach to prevent radioactivity uptake by using acidosis in experimental animals. Indian Journal of Experimental Biology. 2014 Aug; 52(8): 793-798.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153761
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/29297en_US
dc.subjectAcidosisen_US
dc.subjectCesium-137en_US
dc.subjectDecorporationen_US
dc.subjectRadioactivityen_US
dc.subjectRadiometryen_US
dc.subjectThallium-201en_US
dc.subject.meshAnimals
dc.subject.meshCesium Radioisotopes --adverse effects
dc.subject.meshHumans
dc.subject.meshJejunum --drug effects
dc.subject.meshJejunum --radiation effects
dc.subject.meshLactic Acid --administration & dosage
dc.subject.meshMice
dc.subject.meshMuscle, Skeletal --drug effects
dc.subject.meshMuscle, Skeletal --radiation effects
dc.subject.meshRadiation-Protective Agents --administration & dosage
dc.subject.meshRats
dc.subject.meshThallium Radioisotopes --adverse effects
dc.subject.meshWhole-Body Irradiation --adverse effects
dc.titleEvaluation of a novel decorporation approach to prevent radioactivity uptake by using acidosis in experimental animals.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijeb2014v52n8p793.pdf
Size:
208.44 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Experimental Biology