Newborn Screening and Clinical Profile of Children With Sickle Cell Disease in a Tribal Area of Gujarat

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dc.contributor.authorDave, Kapilkumaren_US
dc.contributor.authorDesai, Shreyen_US
dc.contributor.authorItalia, Yazdien_US
dc.contributor.authorMukherjee, Malay Ben_US
dc.contributor.authorMehta, Pallavien_US
dc.contributor.authorDesai, Gayatrien_US
dc.date.accessioned2023-08-25T06:39:29Z
dc.date.available2023-08-25T06:39:29Z
dc.date.issued2022-03
dc.description.abstractObjectives: To present the result of newborn sickle cell disease (SCD) screening and clinical profile of SCD newborns in a tribal area of Gujarat. Methods: We screened all newborns of sickle cell trait (SCT) and SCD mothers for SCD using high-performance liquid chromatography (HPLC) within two days of birth at a secondary care hospital in a tribal area in Gujarat from 2014 to 2019. Newborns with SCD were registered under an information technology based platform for hospital-based comprehensive care. Neonates were followed prospectively every 3 months. If they missed the clinic visit, a medical counsellor visited them at home to collect the required information. Results: Out of 2492 newborns screened, 87 (3.5%) were diagnosed with SCD. Among the 67 newborns screened for alpha-thalassemia deletion, 64 (95.4%) of babies had alpha-thalassemia deletion. We recorded total 554 clinic visits over the period of 221.5 person-years. The rates of acute febrile illness, painful crisis, hospitalization and severe anemia were 42.9, 14.9, 14.9 and 4.5 per 100 person-year, respectively. Two deaths were recorded, and 5 babies (5.7%) had severe SCD. Conclusion: We found a high prevalence of alpha thalassemia deletion among newborn SCD cohort in tribal area of Gujarat, and 70% babies had atleast one clinical complication on follow-up.en_US
dc.identifier.affiliationsSEWA Rural, Jhagadia, Gujaraten_US
dc.identifier.affiliationsValsad Raktadan Kendra, Valsad, Gujaraten_US
dc.identifier.affiliationsNational Institute of Immuno Haematology (ICMR), Mumbai, Maharashtraen_US
dc.identifier.citationDave Kapilkumar, Desai Shrey, Italia Yazdi, Mukherjee Malay B, Mehta Pallavi, Desai Gayatri. Newborn Screening and Clinical Profile of Children With Sickle Cell Disease in a Tribal Area of Gujarat. Indian Pediatrics. 2022 Mar; 59(3): 230-233en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225310
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber3en_US
dc.relation.volume59en_US
dc.source.urihttps://indianpediatrics.net/mar2022/230.pdfen_US
dc.subject?-Thalassemia deletionen_US
dc.subjectFollow-upen_US
dc.subjectMortalityen_US
dc.subjectOutcome.en_US
dc.titleNewborn Screening and Clinical Profile of Children With Sickle Cell Disease in a Tribal Area of Gujaraten_US
dc.typeJournal Articleen_US
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