Influence of melatonin on blood morphology in male albino mice.

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dc.contributor.authorKarimungi, M Gen_US
dc.contributor.authorJoshi, B Nen_US
dc.contributor.authorSaibaba, Pen_US
dc.date.accessioned2009-05-28T13:03:19Z
dc.date.available2009-05-28T13:03:19Z
dc.date.issued1996-08-01en_US
dc.description.abstractInfluence of melatonin on diurnal changes in hematological profiles was examined in male albino mice, at six hourly interval. Melatonin treatment either once daily (25 micrograms at 1700 hrs) or twice daily (25 micrograms at 0900 and 1700 hrs) for two weeks resulted in an alternation in the RBC rhythm. Generally the effect was suppressive though at some times the counts were marginally increased. Total WBC counts were increased and there was apparently a change in their rhythm too. Interestingly the differential WBC counts exhibited different patterns in, once and twice daily melatonin-treated mice. Melatonin given once daily predominantly stimulated the absolute lymphocyte count whereas the twice daily regimen predominantly stimulated the neutrophil count. This perhaps is related to the varied exposures of the animals to melatonin in the two experimental setups. Erythrocyte indices like mean cell volume, mean cell hemolglobin and mean cell hemoglobin concentration in both the experiments correlated with hemoglobin and hematocrit values. It may be concluded that melatonin has a modulatory role in hemopoiesis and its rhythms. The stimulatory effect of melatonin on WBC supports its purported immunopotentiating action.en_US
dc.description.affiliationDepartment of Zoology, Gulbarga University, India.en_US
dc.identifier.citationKarimungi MG, Joshi BN, Saibaba P. Influence of melatonin on blood morphology in male albino mice. Indian Journal of Experimental Biology. 1996 Aug; 34(8): 758-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58902
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCircadian Rhythm --drug effectsen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshHematologic Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin --pharmacologyen_US
dc.subject.meshMiceen_US
dc.titleInfluence of melatonin on blood morphology in male albino mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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