Relation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels.

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dc.contributor.authorSari, Aysegul
dc.contributor.authorDere, Yelda
dc.contributor.authorPakoz, Betul
dc.contributor.authorCalli, Aylin
dc.contributor.authorUnal, Belkis
dc.contributor.authorTunakan, Mine
dc.date.accessioned2012-10-10T04:20:41Z
dc.date.available2012-10-10T04:20:41Z
dc.date.issued2011-04
dc.description.abstractBackground: Hepatitis B virus (HBV) is a potentially life-threatening liver infection which may progress to liver failure and cirrhosis. Intrahepatic expression patterns of viral antigens detected by immunohistochemistry may have prognostic implications in disease process. Aim: In this study, we aimed to investigate the relationship between the HBV core antigen (HBcAg) expression and histological activity index (HAI), fibrosis, serum hepatitis B e-antigen (HBeAg) status and HBV DNA levels in patients with chronic HBV infection. Materials and Methods: A total of 114 liver biopsies from patients with chronic HBV infection were included in the study. Immunohistochemical expression of HBcAg and its relation with HAI, fibrosis, serum alanine aminotransferase (ALT) levels, HBeAg status and HBV DNA levels were assessed. Results: The presence of nuclear expression of HBcAg did not show any correlations with ALT levels, HAI and fibrosis score. When the groups were categorized according to the HBeAg status, nuclear HBcAg expression was found to be high in HBeAg positive patients. However, HBcAg nuclear expression showed significant correlations with HBV DNA levels and fibrosis scores in HBeAg negative but not HBeAg positive patients. HBV DNA levels were also significantly associated with HAI and fibrosis scores in HBeAg negative patients. Conclusions: Significant differences found between HBeAg positive and negative patients suggest that HBeAg negative disease is different from HBeAg positive disease, and also point outs that in HBeAg negative disease, patients with nuclear HBcAg expression and increased levels of HBV DNA levels are at a higher risk of developing progressive liver disease.en_US
dc.identifier.citationSari Aysegul, Dere Yelda, Pakoz Betul, Calli Aylin, Unal Belkis, Tunakan Mine. Relation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels. Indian Journal of Pathology & Microbiology. 2011 Apr-Jun 54(2): 355-358.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/141986
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=2;spage=355;epage=358;aulast=Sarien_US
dc.subjectChronic hepatitisen_US
dc.subjecthepatitis Ben_US
dc.subjecthepatitis B core antigenen_US
dc.subjectimmunohistochemistryen_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAlanine Transaminase --blood
dc.subject.meshBiopsy
dc.subject.meshDNA, Viral --blood
dc.subject.meshFemale
dc.subject.meshGene Expression
dc.subject.meshHepatitis B Core Antigens --biosynthesis
dc.subject.meshHepatitis B e Antigens --blood
dc.subject.meshHepatitis B, Chronic --pathology
dc.subject.meshHepatitis B, Chronic --virology
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshLiver --pathology
dc.subject.meshLiver Cirrhosis --pathology
dc.subject.meshMale
dc.subject.meshMicroscopy
dc.subject.meshMiddle Aged
dc.titleRelation of hepatitis B core antigen expression with histological activity, serum HBeAg, and HBV DNA levels.en_US
dc.typeArticleen_US
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