Accuracy of using 30-minute post-dialysis BUN to determine equilibrated Kt/V.

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dc.contributor.authorChirananthavat, Thaniten_US
dc.contributor.authorTungsanga, Kriangen_US
dc.contributor.authorEiam-Ong, Somchaien_US
dc.date.accessioned2009-05-27T21:44:38Z
dc.date.available2009-05-27T21:44:38Z
dc.date.issued2006-08-19en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: The equilibrated Kt/V (eKt/V), a clinical index of hemodialysis adequacy, can be calculated by several means. The commonly used methods are second generation of natural logarithm by Daugirdas and rate adjustment methods. However these two methods used immediate post-dialysis blood urea nitrogen (BUN) (C0). The authors investigated the accuracy of 30-minute post-dialysis BUN (C30), equilibrated BUN at the end of urea rebound time, to determine the eKt/V MATERIAL AND METHOD: We measured 7 values of eKt/V in 30 hemodialysis sessions by using the 5 following methods: 1). Empirical method (Emp) 2). Smye method (Sm) 3). Daugirdas method using C0 and C30 (Dau0, Dau30) 4). Rate adjustment method using C0 and C30 (Rate0, Rate30) 5). Double Pool urea kinetic model (DP), and compared with the gold standard values calculated by the modified Direct Dialysate Quantitative method (mDDQ). RESULTS: All patients had adequate hemodialysis with eKt/V (mDDQ) = 1.80 + 0.22. Compared with mDDQ, the median of absolute difference of eKt/V were Rate30 (0.10); Dau30 (0.11), Rate0 (0.11), Sm (0.11); Emp (0.13); DP (0.15); Dau0 (0.35) while the correlation coefficient (r2) were 0.926, 0.948, 0.785, 0.629, 0.551, 0.833,and 0.806 respectively. CONCLUSION: By using 30-minute post-dialysis BUN to calculate, the values of eKt/V by Daugirdas and rate adjustment methods were associated with better accuracy and correlation than immediate post-dialysis BUN. In the demand of the accurate eKt/V measurement, the Dau30 and Rate30 may be the suitable method to determine the eKt/V in clinical hemodialysis.en_US
dc.description.affiliationDivision of Nephrology, Department of Medicine, Police General Hospital, Bangkok, Thailand.en_US
dc.identifier.citationChirananthavat T, Tungsanga K, Eiam-Ong S. Accuracy of using 30-minute post-dialysis BUN to determine equilibrated Kt/V. Journal of the Medical Association of Thailand. 2006 Aug; 89 Suppl 2(): S54-64en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45325
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshBlood Urea Nitrogenen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Chronic --blooden_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshRenal Dialysisen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshUrea --blooden_US
dc.titleAccuracy of using 30-minute post-dialysis BUN to determine equilibrated Kt/V.en_US
dc.typeJournal Articleen_US
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