Central diabetes insipidus: clinical profile and factors indicating organic etiology in children.

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dc.contributor.authorBajpai, Anuragen_US
dc.contributor.authorKabra, Madhulikaen_US
dc.contributor.authorMenon, P S Nen_US
dc.date.accessioned2008-06-05en_US
dc.date.accessioned2009-05-27T06:07:01Z
dc.date.available2008-06-05en_US
dc.date.available2009-05-27T06:07:01Z
dc.date.issued2008-06-05en_US
dc.description.abstractOBJECTIVE: To evaluate the profile of children with central diabetes insipidus (DI) and identify factors indicating organic etiology. DESIGN: Retrospective chart review. SETTING: Tertiary referral hospital. SUBJECTS: Fifty-nine children with central DI (40 boys, 19 girls). METHODS: Features of organic and idiopathic central DI were compared using students t test and chi square test. Odds ratio was calculated for factors indicating organic etiology. RESULTS: Diagnosis included post-operative central DI (13, 22%), central nervous system (CNS) malformations (5, 8.6% holoprosencephaly 4 and hydrocephalus 1), histiocytosis (11, 18.6%), CNS pathology (11, 18.6%; craniopharyngioma 3, empty sella 2, germinoma 2, neuro-tuberculosis 2, arachnoid cyst 1 and glioma 1) and idiopathic central DI (19, 32.2%). Children with organic central DI were diagnosed later (7.8+/- 3.1 years against 5.3+/-2.4 years, P=0.03) and had lower height standard deviation score (-2.7+/-1.0 versus -1.0+/- 1.0, P<0.001) compared to idiopathic group. A greater proportion of children with organic central DI had short stature (81.8% against 10.5%, P <0.001, odds ratio 38.25), neurological features (45.5% against 0%, p 0.009) and anterior pituitary hormone deficiency (81.8% against 5.3%, P<0.001, odds ratio 81) compared to idiopathic group. A combination of short stature and onset after five years of age led to discrimination of organic central DI from idiopathic group in all cases. CONCLUSION: Organic central DI should be suspected in children presenting after the age of five years with growth retardation and features of anterior pituitary deficiency.en_US
dc.description.affiliationDivision of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.en_US
dc.identifier.citationBajpai A, Kabra M, Menon PS. Central diabetes insipidus: clinical profile and factors indicating organic etiology in children. Indian Pediatrics. 2008 Jun; 45(6): 463-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/15013
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAdolescenten_US
dc.subject.meshCentral Nervous System Diseases --complicationsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDiabetes Insipidus --diagnosisen_US
dc.subject.meshDiabetes Insipidus, Neurogenic --diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.titleCentral diabetes insipidus: clinical profile and factors indicating organic etiology in children.en_US
dc.typeJournal Articleen_US
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