Autoantibodies in thalassaemia major: relationship with oral iron chelator L1.

Simple item page
dc.contributor.authorMehta, Jen_US
dc.contributor.authorChablani, Aen_US
dc.contributor.authorReporter, Ren_US
dc.contributor.authorSinghal, Sen_US
dc.contributor.authorMehta, B Cen_US
dc.date.accessioned1993-06-01en_US
dc.date.accessioned2009-05-30T23:00:28Z
dc.date.available1993-06-01en_US
dc.date.available2009-05-30T23:00:28Z
dc.date.issued1993-06-01en_US
dc.description.abstractNinety patients with thalassaemia major were investigated for the occurrence of antinuclear antibodies (ANA), and those with ANA were tested for antibodies to histones (AHA). ANA were detected in 7 of 27 thalassemics on oral iron chelator L1, and in 2 of 63 thalassaemics not on L1 (p < 0.01). AHA were seen in 4 of 7 thalassemics receiving L1 with positive ANA, and in none of the 2 not receiving L1 (p < 0.03). Joint pains were seen in patients receiving L1, but in none of the patients not receiving L1. There was no correlation between hepatitis B or HIV positivity and presence of ANA or joint pains. While some amount of background ANA-positivity was found in patients with thalassaemia major, it was significantly more in patients receiving L1. Laboratory evidence of drug-induced lupus-like reaction was seen only in patients who received L1. In view of serious concerns about the safety of L1 and wide variations in the incidence and severity of adverse reactions reported by different sources, an urgent regulatory audit of all trial centres is essential.en_US
dc.description.affiliationBlood Research Centre, Bombay.en_US
dc.identifier.citationMehta J, Chablani A, Reporter R, Singhal S, Mehta BC. Autoantibodies in thalassaemia major: relationship with oral iron chelator L1. Journal of the Association of Physicians of India. 1993 Jun; 41(6): 339-41en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/90039
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Antinuclear --blooden_US
dc.subject.meshAutoimmune Diseases --chemically induceden_US
dc.subject.meshBlood Transfusionen_US
dc.subject.meshChilden_US
dc.subject.meshDeferoxamine --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemosiderosis --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshIron --blooden_US
dc.subject.meshIron Chelating Agents --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshPyridones --administration & dosageen_US
dc.subject.meshThalassemia --immunologyen_US
dc.titleAutoantibodies in thalassaemia major: relationship with oral iron chelator L1.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Association of Physicians of India