Inducible protective processes in animal systems: adaptive response to a low dose of methyl methanesulfonate in mouse bone marrow cells.

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dc.contributor.authorMahmood, Ren_US
dc.contributor.authorVasudev, Ven_US
dc.contributor.authorHarish, S Ken_US
dc.contributor.authorGuruprasad, K Pen_US
dc.date.accessioned2009-05-28T10:43:41Z
dc.date.available2009-05-28T10:43:41Z
dc.date.issued1996-06-01en_US
dc.description.abstractTo investigate the induction of adaptive response (inducible protective processes) in mitotic cells of Swiss albino mouse, a monofunctional alkylating agent methyl methanesulfonate (MMS) was employed. When the animals treated with a low dose of 50 mg/kg body weight were challenged with a subsequent high (challenging) dose of 150 mg/kg body weight, after different time lags (2,5,8 or 10 hr), the yield of chromosomal aberrations in bone marrow cells was found to be significantly reduced compared to the additive effects of both conditioning and challenging doses. It seems, therefore, that the low dose of MMS employed has made the cells less sensitive against further clastogenic effect of challenge dose of MMS. The data clearly suggest that the phenomenon of adaptive response to methylating agents can be encountered in in vivo mammalian cells. Furthermore, it is also observed that ethylating agent EMS is a poor inducer of adaptive response than its corresponding methylating agent MMS in the bone marrow cells of mouse.en_US
dc.description.affiliationDepartment of Studies in Zoology, University of Mysore, Manasagangotri, India.en_US
dc.identifier.citationMahmood R, Vasudev V, Harish SK, Guruprasad KP. Inducible protective processes in animal systems: adaptive response to a low dose of methyl methanesulfonate in mouse bone marrow cells. Indian Journal of Experimental Biology. 1996 Jun; 34(6): 502-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55713
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdaptation, Physiologicalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents, Alkylating --pharmacologyen_US
dc.subject.meshBone Marrow --drug effectsen_US
dc.subject.meshBone Marrow Cellsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshMaleen_US
dc.subject.meshMethyl Methanesulfonate --pharmacologyen_US
dc.subject.meshMiceen_US
dc.titleInducible protective processes in animal systems: adaptive response to a low dose of methyl methanesulfonate in mouse bone marrow cells.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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