Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease

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dc.contributor.authorSancheti, Saurabhen_US
dc.contributor.authorShah, Prasaden_US
dc.contributor.authorPhalgune, Deepak S.en_US
dc.date.accessioned2020-01-02T06:40:14Z
dc.date.available2020-01-02T06:40:14Z
dc.date.issued2018-09
dc.description.abstractObjectives Brachial artery ultrasound imaging during reactive hyperemia is widely used tool for quantifying endothelium dependent vasomotion. Angiodefender device is used for non invasive determination of percentage flow mediated vasodilation (FMD). An attempt is made to study whether endothelial dysfunction determined by FMD of brachial artery predicts the presence or absence of coronary artery disease and its correlation with the severity of coronary artery disease. Methods One hundred six patients admitted between May 2014 and April 2015 who were posted for coronary angiography diagnosed to have chronic stable angina on clinical basis and/or by exercise stress test, for evaluation of coronary artery disease were submitted to standard clinical evaluation, calculation of percentage FMD by Angiodefender device. Statistical significance of difference of categorical variables was tested using Fisher’s exact test. Sensitivity, specificity, positive predictive value and negative predictive value of FMD were studied. Results There was no correlation between number of risk factors and percentage of FMD. Significantly higher proportion of cases with less FMD had higher prevalence of coronary artery disease and vice-versa. Significantly higher proportion of cases with positive stress test had less percentage of FMD and vice-versa. Significantly higher proportion of cases with less percentage of FMD and positive stress test had higher prevalence of obstructive coronary artery disease and vice-versa. Specificity was 100% when percentage of FMD was ≤10. Conclusions FMD an inexpensive and non-invasive test provides information regarding extent and severity of coronary artery disease.en_US
dc.identifier.affiliationsDept. of Cardiology, Poona Hospital & Research Centre, Pune, Indiaen_US
dc.identifier.citationSancheti Saurabh, Shah Prasad, Phalgune Deepak S.. Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease. Indian Heart Journal. 2018 Sep; 70(5): 622-626en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/191655
dc.languageenen_US
dc.publisherCardiological Society of Indiaen_US
dc.relation.issuenumber5en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2018.01.008en_US
dc.subjectCoronary angiographyen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectFlow mediated vasodilatationen_US
dc.subjectStress testen_US
dc.titleCorrelation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery diseaseen_US
dc.typeJournal Articleen_US
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