Antifilarial activity of Caesalpinia bonducella against experimental filarial infections.

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dc.contributor.authorGaur, R Len_US
dc.contributor.authorSahoo, M Ken_US
dc.contributor.authorDixit, Sen_US
dc.contributor.authorFatma, Nen_US
dc.contributor.authorRastogi, Sen_US
dc.contributor.authorKulshreshtha, D Ken_US
dc.contributor.authorChatterjee, R Ken_US
dc.contributor.authorMurthy, P Ken_US
dc.date.accessioned2008-07-30en_US
dc.date.accessioned2009-05-27T07:51:51Z
dc.date.available2008-07-30en_US
dc.date.available2009-05-27T07:51:51Z
dc.date.issued2008-07-30en_US
dc.description.abstractBACKGROUND & OBJECTIVE: Lymphatic filariasis is a disabling disease that continues to cripple population in tropical countries. Currently available antifilarial drugs are not able to control the disease. Therefore, a better antifilarial is urgently required for proper management of the disease. We undertook this study to assess the antifilarial activity of Caesalpinia bonducella-seed kernel against rodent filarial parasite in experimental model. METHODS: Microfilaraemic cotton rats and Mastomys coucha harbouring Litomosoides sigmodontis and Brugia malayi respectively, were treated with crude extract or fractions of the seed kernel C. bonducella through oral route for 5 consecutive days. Microfilaricidal, macrofilaricidal and female worm sterilizing efficacy was assessed. RESULTS: Crude extract showed gradual fall in microfilariae (mf) count in L. sigmodontis-cotton rat model from day 8 post-treatment attaining more than 95 per cent fall by the end of observation period. It also exhibited 96 per cent macrofilaricidal and 100 per cent female sterilizing efficacy. The butanol fraction F018 caused 73.7 per cent reduction in mf count and 82.5 per cent mortality in adult worms with 100 per cent female sterilization. The aqueous fraction F019 exerted more than 90 per cent microfilaricidal activity and 100 per cent worm sterilization. Two chromatographic fractions, F024 and F025 of hexane soluble fraction exhibited 64 and 95 per cent macrofilaricidal activity, respectively. Both the fractions caused gradual fall in microfilaraemia and 100 per cent worm sterilization. In B. malayi-M. coucha model F025 showed gradual reduction in microfilaraemia and caused 80 per cent sterilization of female parasites INTERPRETATION & CONCLUSION: In conclusion, C. bonducella- seed kernel extract and fractions showed microfilaricidal, macrofilaricidal and female-sterilizing efficacy against L. sigmodontis and microfilaricidal and female-sterilizing efficacy against B. malayi in animal models, indicating the potential of this plant in providing a lead for new antifilarial drug development.en_US
dc.description.affiliationDivisions of Parasitology, Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.citationGaur RL, Sahoo MK, Dixit S, Fatma N, Rastogi S, Kulshreshtha DK, Chatterjee RK, Murthy PK. Antifilarial activity of Caesalpinia bonducella against experimental filarial infections. Indian Journal of Medical Research. 2008 Jul; 128(1): 65-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/22360
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrugia malayi --drug effectsen_US
dc.subject.meshCaesalpiniaen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshElephantiasis, Filarial --drug therapyen_US
dc.subject.meshFilarioidea --drug effectsen_US
dc.subject.meshPhytotherapy --methodsen_US
dc.subject.meshPlant Preparations --pharmacologyen_US
dc.subject.meshSeedsen_US
dc.subject.meshSigmodontinaeen_US
dc.titleAntifilarial activity of Caesalpinia bonducella against experimental filarial infections.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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