Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats.

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dc.contributor.authorNair, Vinod
dc.contributor.authorArjuman, Albina
dc.contributor.authorGopalakrishna, H N
dc.contributor.authorDorababu, P
dc.contributor.authorMirshad, P V
dc.contributor.authorBhargavan, Divya
dc.contributor.authorChatterji, Dipsanker
dc.date.accessioned2011-11-30T08:42:15Z
dc.date.available2011-11-30T08:42:15Z
dc.date.issued2010-08
dc.description.abstractBackground & objectives: The aetiology of gastric ulcers is not completely understood and continuous use of anti-ulcer agents leads to many side effects. In this study we evaluated the anti-ulcer efficacy of a polyherbal formulation with potent antioxidant activity in aspirin and pyloric ligature induced gastric ulcers in rats. Methods: The efficacy of the polyherbal formulation NR-ANX-C (composed of the extracts from Withania somnifera, Camellia sinensis, Ocimum sanctum, shilajith and triphala) was evaluated in terms of antioxidant potential as assessed in terms of protection from lipid peroxidation and the antiulcer activity as seen by the area of gastric lesions, gastric juice volume, gastric pH, total acidity and total adherent gastric mucus content. Results: In our study, NR-ANX-C (25 and 50 mg/kg) was more efficacious than ranitidine in reducing ulcer index in both the models. At the highest dose tested (50 mg/kg), NR-ANX-C was comparable to omeprazole in preventing ulcer formation in the pyloric ligature model. NR-ANX-C showed a dose- dependent decrease in gastric juice volume and total acidity in both the models. A dose-dependent increase in gastric pH and total adherent gastric mucus was also seen in NR-ANX-C treated groups. The extent of lipid peroxidation was also reduced in the test drug treated groups. Interpretation & conclusion: Based on our findings, we presume that the cytoprotective, anti-secretary and antioxidant properties of NR-ANX-C were responsible for its anti-ulcer activity. These findings suggest the potential for use of NR-ANX-C as an adjuvant in the treatment of gastric ulcer.en_US
dc.identifier.citationNair Vinod, Arjuman Albina, Gopalakrishna H N, Dorababu P, Mirshad P V, Bhargavan Divya, Chatterji Dipsanker. Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats. Indian Journal of Medical Research. 2010 Aug; 132(2): 218-223.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135565
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2010/august/0813.pdfen_US
dc.subjectAntioxidanten_US
dc.subjectCamellia sinensisen_US
dc.subjectgastric ulceren_US
dc.subjectOcimum sanctumen_US
dc.subjectshilajiten_US
dc.subjecttriphalaen_US
dc.subjectWithania somniferaen_US
dc.subject.meshAnalysis of Variance
dc.subject.meshAnimals
dc.subject.meshAnti-Ulcer Agents --pharmacology
dc.subject.meshAnti-Ulcer Agents --therapeutic use
dc.subject.meshAspirin --pharmacology
dc.subject.meshAspirin --therapeutic use
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshMale
dc.subject.meshMalondialdehyde --metabolism
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Extracts --therapeutic use
dc.subject.meshRats
dc.subject.meshRats, Mutant Strains
dc.subject.meshStomach Ulcer --drug therapy
dc.subject.meshStomach Ulcer --etiology
dc.subject.meshThiobarbituric Acid Reactive Substances
dc.titleEvaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats.en_US
dc.typeArticleen_US
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