Surfactant protein-A: new insights into an old protein--Part I.

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dc.contributor.authorKumar, A Ren_US
dc.contributor.authorSnyder, J Men_US
dc.date.accessioned1998-09-25en_US
dc.date.accessioned2009-05-30T12:55:17Z
dc.date.available1998-09-25en_US
dc.date.available2009-05-30T12:55:17Z
dc.date.issued1998-09-25en_US
dc.description64 references.en_US
dc.description.abstractPulmonary surfactant is a lipoprotein substance that lines the lungs and helps reduce surface tension. Surfactant associated protein-A (SP-A) is the most abundant non-serum protein in pulmonary surfactant. This complex glycoprotein aids in the synthesis, secretion and recycling of surfactant phospholipids, and facilitates the reduction of surface tension by surfactant phospholipids. Recent evidence has highlighted the role of SP-A in the innate immune system present in the lung. SP-A may play a major role in defense against pathogens by interacting with both infectious agents and the immune system. Factors that affect fetal lung maturation, e.g., gestational age and hormones, regulate SP-A gene expression. Mediators of immune function also regulate SP-A levels. A number of lung disorders, including infectious diseases and respiratory distress syndrome are associated with abnormal alveolar SP-A levels. SP-A can no longer be called a lung-specific protein, since it has recently been detected in other tissues. In most species, SP-A is encoded by a single gene, however in humans it is encoded by two, very similar genes. Models for the structure of the human SP-A protein molecule have been proposed, suggesting that the mature alveolar SP-A molecule is composed of both gene products. The study of SP-A may provide information helpful in understanding disease processes and formulating new treatment modalities.en_US
dc.description.affiliationDepartment of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City 52242, USA.en_US
dc.identifier.citationKumar AR, Snyder JM. Surfactant protein-A: new insights into an old protein--Part I. Indian Journal of Pediatrics. 1998 Sep-Oct; 65(5): 629-41en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/81171
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshGene Expression --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLung --pathologyen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshProteolipids --geneticsen_US
dc.subject.meshPulmonary Surfactant-Associated Protein Aen_US
dc.subject.meshPulmonary Surfactant-Associated Proteinsen_US
dc.subject.meshPulmonary Surfactants --geneticsen_US
dc.subject.meshRespiratory Distress Syndrome, Newborn --physiopathologyen_US
dc.subject.meshRespiratory Tract Infections --physiopathologyen_US
dc.subject.meshSurface Tensionen_US
dc.titleSurfactant protein-A: new insights into an old protein--Part I.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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