Clinicopathological profile of hepatic involvement in type-2 diabetes mellitus and its significance.

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dc.contributor.authorBanerjee, Sen_US
dc.contributor.authorGhosh, U Sen_US
dc.contributor.authorDutta, Sen_US
dc.date.accessioned2008-08-05en_US
dc.date.accessioned2009-05-31T03:32:47Z
dc.date.available2008-08-05en_US
dc.date.available2009-05-31T03:32:47Z
dc.date.issued2008-08-05en_US
dc.description.abstractAIMS AND OBJECTIVES: Involvement of liver as an organ complication in Type 2 Diabetes Mellitus (T2DM) is known. Studies are few about their baseline parameters from our country. Study the disease burden and clinicopathological profile of hepatic involvement in T2DM, find the associations with known risk factors and thus try to identify simple markers of advanced disease. MATERIAL AND METHODS: A screened group of randomly selected 47 patients of T2DM without other liver diseases (viral, alcoholic, drug, autoimmune, etc.) was selected. Their clinical (age, sex, body mass index, family history, blood pressure), biochemical (transaminases, lipid profile), and hepatic ultrasonographic (USG) and histopathological (HPE) profiles were studied. Segregation was done according to the histological severity and duration of diabetes (< 5 yrs, 5-10 yrs, > 10 yrs). RESULTS: On histology, normalcy was maintained in 17%, only fatty change was present in 43%, nonalcoholic steatohepatitis (NASH) could be identified in 40% with more advanced disease in 23%. Prevalence of cirrhosis was low. Positive family history, hypertension, longer duration, female sex and increased body mass index were significantly associated with NASH; more advanced disease was associated with male sex only. Incident lipid profile and transaminases levels were non-contributory. In the early stage, USG detected abnormality correlated poorly with HPE. CONCLUSION: The burden of hepatopathy in T2DM is high; with improving cardiovascular mortality, a higher burden awaits us in the next decade or so. Naturally, it becomes imperative to the treating clinician for targeting this aspect of diabetic complication from the very beginning of therapy.en_US
dc.description.affiliationDepartment of Medicine, Vivekananda Institute of Medical Sciences, Kolkata.en_US
dc.identifier.citationBanerjee S, Ghosh US, Dutta S. Clinicopathological profile of hepatic involvement in type-2 diabetes mellitus and its significance. Journal of the Association of Physicians of India. 2008 Aug; 56(): 593-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/93994
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshDiabetes Complicationsen_US
dc.subject.meshDiabetes Mellitus, Type 2 --complicationsen_US
dc.subject.meshEpidemiologic Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --physiopathologyen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshLiver --physiopathologyen_US
dc.subject.meshLiver Diseases --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screeningen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Factorsen_US
dc.titleClinicopathological profile of hepatic involvement in type-2 diabetes mellitus and its significance.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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