Arsenic induced free radical toxicity in brain of mice.

Simple item page
dc.contributor.authorRao, M Ven_US
dc.contributor.authorAvani, Gen_US
dc.date.accessioned2009-05-28T14:44:22Z
dc.date.available2009-05-28T14:44:22Z
dc.date.issued2004-05-06en_US
dc.description.abstractThe present study was designed to investigate the in vivo effects of oral administration of arsenic trioxide (As2O3; 0.5 and 1 mg/kg body weight/day for 45 days) on cerebral hemispheres and cerebellum in male mice, Mus musculus. Arsenic reduced the concentration of glutathione (GSH) in cerebral hemisphere and cerebellum at both the dose levels; while increased lipid peroxidation (LPO) in cerebral hemisphere and cerebellum regions. Further, the activities of antioxidant enzymes viz., superoxide dismutase and catalase also declined in these two regions with dose indicating oxidative stress. This effect is caused by the action of reactive oxygen species (ROS) induced by arsenic exposure.en_US
dc.description.affiliationDepartment of Zoology, University School of Sciences, Gujarat University, Navrangpura, Ahmedabad 380 009, India. zooldeptgu@satyam.net.inen_US
dc.identifier.citationRao MV, Avani G. Arsenic induced free radical toxicity in brain of mice. Indian Journal of Experimental Biology. 2004 May; 42(5): 495-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61096
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArsenic --toxicityen_US
dc.subject.meshBrain --drug effectsen_US
dc.subject.meshCerebellum --drug effectsen_US
dc.subject.meshFree Radicalsen_US
dc.subject.meshGlutathione --metabolismen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshOxygen --metabolismen_US
dc.subject.meshReactive Oxygen Speciesen_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.subject.meshTelencephalon --drug effectsen_US
dc.titleArsenic induced free radical toxicity in brain of mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology