Type II diabetes mellitus and obesity: Common links, existing therapeutics and future developments

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dc.contributor.authorBanerjee, Subhadeepen_US
dc.contributor.authorTalukdar, Indranien_US
dc.contributor.authorBanerjee, Arnaben_US
dc.contributor.authorGupta, Arnaven_US
dc.contributor.authorBalaji, Advaiten_US
dc.contributor.authorAduri, Raviprasaden_US
dc.date.accessioned2020-11-18T10:14:14Z
dc.date.available2020-11-18T10:14:14Z
dc.date.issued2019-12
dc.description.abstractType II diabetes mellitus (T2DM) and obesity are two common pathophysiological conditions of metabolic syndrome(MetS), a collection of similar metabolic dysfunctions due to sedentary lifestyle and overnutrition. Obesity arises fromimproper adipogenesis which otherwise has a crucial role in maintaining proper metabolic functions. Downstream eventsarising from obesity have been linked to T2DM. The nuclear receptor peroxisome proliferator activator gamma (PPAR-c),responsible for maintaining lipid and glucose homeostasis, is down-regulated under obesity leading to a weakened insulinsensitivity of the human body. In course of our review we will outline details of the down-regulation mechanism, provide anoverview of the current clinical therapeutics and their shortcomings. Toxicity studies on the seminal drug troglitazone,belonging to the most effective glitazone anti-diabetic category, is also discussed. This will lead to an overview aboutstructural adaptations on the existing glitazones to alleviate their side effects and toxicity. Finally, we forward a concept ofnovel therapeutics mimicking the glitazone framework, based on some design concepts and preliminary in silico studies.These could be later developed into dual acting drugs towards alleviating the deleterious effects of obesity on normalglucose metabolism, and address obesity in itself.en_US
dc.identifier.affiliationsDepartment of Chemistry, BITS Pilani, K K Birla Goa Campus, Zuarinagar 403 726, Goa, Indiaen_US
dc.identifier.affiliationsDepartment of Biological Sciences, BITS Pilani, K K Birla Goa Campus, Zuarinagar 403 726, Goa, Indiaen_US
dc.identifier.affiliationsDepartment of Biological Sciences, BITS Pilani, K K Birla Goa Campus, Zuarinagar 403 726, Goa, Indiaen_US
dc.identifier.affiliationsDepartment of Biological Sciences, BITS Pilani, K K Birla Goa Campus, Zuarinagar 403 726, Goa, Indiaen_US
dc.identifier.affiliationsDepartment of Biological Sciences, BITS Pilani, K K Birla Goa Campus, Zuarinagar 403 726, Goa, Indiaen_US
dc.identifier.affiliationsDepartment of Biological Sciences, BITS Pilani, K K Birla Goa Campus, Zuarinagar 403 726, Goa, Indiaen_US
dc.identifier.citationBanerjee Subhadeep, Talukdar Indrani, Banerjee Arnab, Gupta Arnav, Balaji Advait, Aduri Raviprasad. Type II diabetes mellitus and obesity: Common links, existing therapeutics and future developments. Journal of Biosciences. 2019 Dec; 44(6): 1-13en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214218
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.issuenumber6en_US
dc.relation.volume44en_US
dc.source.urihttps://dx.doi.org//10.1007/s12038-019-9962-7en_US
dc.subjectT2DMen_US
dc.subjectobesityen_US
dc.subjectPPAR-gammaen_US
dc.subjectTNF-alphaen_US
dc.subjectSPPAR-gamma-Msen_US
dc.subjectglitazonesen_US
dc.titleType II diabetes mellitus and obesity: Common links, existing therapeutics and future developmentsen_US
dc.typeJournal Articleen_US
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