Human seminal proteinase and prostate-specific antigen are the same protein.

Simple item page
dc.contributor.authorWaheed, Abdulen_US
dc.contributor.authorHassan, Md Imtaiyazen_US
dc.contributor.authorEtten, Robert L Vanen_US
dc.contributor.authorAhmad, Faizanen_US
dc.date.accessioned2008-06-07en_US
dc.date.accessioned2009-06-01T14:27:31Z
dc.date.available2008-06-07en_US
dc.date.available2009-06-01T14:27:31Z
dc.date.issued2008-06-07en_US
dc.description.abstractHuman seminal proteinase and prostate-specific antigen (PSA) were each isolated from human seminal fluid and compared. Both are glycoproteins of 32-34 kDa with protease activities. Based on some physicochemical,enzymatic and immunological properties,it is concluded that these proteins are in fact identical.The protein exhibits properties similar to kallikrein-like serine protease, trypsin,chymotrypsin and thiol acid protease.Tests of the activity of the enzyme against some potential natural and synthetic substrates showed that bovine serum albumin was more readily hydrolysed than casein.The results of this study should be useful in purifying and assaying this protein.Based on published studies and the present results,the broad proteolytic specificity of human seminal proteinase suggests a role for this protein in several physiological functions.en_US
dc.description.affiliationEdward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, MO 63104, USA.en_US
dc.identifier.citationWaheed A, Hassan MI, Etten RL, Ahmad F. Human seminal proteinase and prostate-specific antigen are the same protein. Journal of Biosciences. 2008 Jun; 33(2): 195-207en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110842
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshChromatography, Gelen_US
dc.subject.meshChromatography, Ion Exchangeen_US
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPeptide Hydrolases --metabolismen_US
dc.subject.meshPeptide Mappingen_US
dc.subject.meshProstate-Specific Antigen --metabolismen_US
dc.subject.meshSemen --enzymologyen_US
dc.titleHuman seminal proteinase and prostate-specific antigen are the same protein.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, N.I.H., Extramuralen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of Biosciences