Correlative analysis of histological profile of the adjoining liver parenchyma with liver enzyme levels in hepatocellular carcinoma and their comparison with chronic liver disease in autopsy cases.

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dc.contributor.authorVaiphei, Kimen_US
dc.date.accessioned2007-10-01en_US
dc.date.accessioned2009-05-29T10:48:14Z
dc.date.available2007-10-01en_US
dc.date.available2009-05-29T10:48:14Z
dc.date.issued2007-10-01en_US
dc.description.abstractThe exact mechanism and aetiological factor for hepatocarcinogenesis is not yet well defined. Besides genomic integration of hepatitis B viral particles, persistent chronic inflammation is postulated to be important initiating factor in viral related hepatocellular carcinoma (HCC). The objectives of the present study were--to correlate histological profiles of chronic liver disease in the adjoining non-tumor liver tissue in HCC with liver enzymes, to compare with those of non-carcinomatous chronic liver disease cases using the liver tissue and data collected at autopsy, and to correlate with hepatitis B and C positive status. Post mortem liver and data available at autopsy were used for the study. Changes of chronic liver disease was graded and staged according to Peter Scheur's (1991). In HCC, the non-malignant liver tissue was used for the study. Hepatitis B surface and core antibodies were demonstration by immunohistochemistry. HCV was documented by RT-PCR using the tissue extract of paraffin embedded liver tissue. HCC group had higher inflammatory grading and transaminases levels than non-HCC group. HBcAg alone and dual HBcAg and HCV positive cases were more in HCC group. Incidence of biliary epithelial cell injury was higher in HCV positive subgroup. Conclusion: higher incidence of inflammatory grading and enzyme level in alone HBcAg and dual HBcAg and HCV positivity in HCC group would suggest significant role of ongoing persistent chronic inflammation and actively replicating HBV and HCV infections in carcinogenesis.en_US
dc.description.affiliationDepartment of Histopathology, PGIMER, Chandigarh. kvaiphei@gmail.comen_US
dc.identifier.citationVaiphei K. Correlative analysis of histological profile of the adjoining liver parenchyma with liver enzyme levels in hepatocellular carcinoma and their comparison with chronic liver disease in autopsy cases. Indian Journal of Pathology & Microbiology. 2007 Oct; 50(4): 711-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/72829
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAutopsyen_US
dc.subject.meshCarcinoma, Hepatocellular --enzymologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepacivirus --geneticsen_US
dc.subject.meshHepatitis B Core Antigens --analysisen_US
dc.subject.meshHepatitis B Surface Antigens --analysisen_US
dc.subject.meshHepatitis, Chronic --enzymologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation --pathologyen_US
dc.subject.meshLiver --chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRNA, Viral --geneticsen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTransaminases --analysisen_US
dc.titleCorrelative analysis of histological profile of the adjoining liver parenchyma with liver enzyme levels in hepatocellular carcinoma and their comparison with chronic liver disease in autopsy cases.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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