Hematological Profile And Serum Potassium Level In Patients Of Chronic Renal Failure At A Tertiary Health Care Center
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Date
2019-10
Authors
Yogi, Jai Prakash
Fiza, Bushra
Godara, Suraj
Sinha, Maheep
Journal Title
Journal ISSN
Volume Title
Publisher
Sumathi Publications
Abstract
Background: Chronic Kidney Disease (CKD) can be defined as an estimated glomerular Filtration Rate (eGFR) of less than 60 ml/min/1.73 m2for a minimum period of three months. CKD is commonly associated with various hema-tological abnormalities especially anemia. Aim: The present study was planned to assess the hematological variations in CKD patients as compared to healthy subjects. Method: Fifty patients diagnosed with CKD were enrolled for the study. Fifty age and sex-matched healthy subjects constituted the control group. Blood samples were collected for all subjects enrolled in the study and subjected to analysis including complete blood count (CBC) using five parts cell counter and renal function test (RFT), including urea, creatinine using dry chemistry, and potassium using direct ion-selective electrode method. Result: On comparison of the hematological profile, it was observed that all enrolled CKD patients were anemic with hemoglobin (Hb) less than 13g/dL in males and less than 12 g/dL in females. The mean Hb levels were as low as 7.50 ± 1.55 g/dL (P< 0.0001). Correspondingly, total RBC count of CKD patients was also low. It was also observed that platelet count was slightly low among CKD patients. However, the mean level was compara-ble with control group (P=NS). On further analysis, it was observed that among fifty CKD patients, 46% (n=23) suf-fered from severe anemia i.e. Hb < 7 gm/dL, whereas 48% had moderate anemia i.e. Hb between 7-9.9 gm/dL. How-ever, only 12 % (n=6) CKD patients suffered from thrombocytopenia i.e. platelets count < 1.50 lack/cmm. Conclu-sion: Hematological abnormalities may lead to several associated morbidities and may pose a challenge for mainte-nance of overall health status for CKD patients. Hence, there is need to monitor hematological profile of CKD patients specially those on dialysis so that any abnormality can be detected and managed accordingly.
Description
Keywords
Chronic kidney disease, Anemia, Hematological changes, Potassium, Platelets.
Citation
Yogi Jai Prakash, Fiza Bushra, Godara Suraj, Sinha Maheep . Hematological Profile And Serum Potassium Level In Patients Of Chronic Renal Failure At A Tertiary Health Care Center. International Journal of Clinical and Biomedical Research. 2019 Oct; 5(4): 1-4