Prevalence and aetiology of anaemia in lymphoid malignancies.

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dc.contributor.authorGHOSH, J
dc.contributor.authorBIKRAMJIT SINGH, R K
dc.contributor.authorSAXENA, R
dc.contributor.authorGUPTA, R
dc.contributor.authorVIVEKANANDAN, S
dc.contributor.authorSREENIVAS, V
dc.contributor.authorRAINA, V
dc.contributor.authorSHARMA, A
dc.contributor.authorKUMAR, L
dc.date.accessioned2015-02-25T04:41:08Z
dc.date.available2015-02-25T04:41:08Z
dc.date.issued2013-03
dc.description.abstractBackground. We prospectively studied the prevalence, type and causes of anaemia in newly diagnosed patients with lymphoid malignancies. Methods. Between January 2007 and June 2008, a total of 316 newly diagnosed, consecutive patients (aged 15 years or above) of Hodgkin lymphoma, non-Hodgkin lymphoma and chronic lymphocytic leukaemia with anaemia (haemoglobin <11 g/dl), were analysed to determine the prevalence and a subgroup of 46 patients was analysed for the cause of anaemia. Results. Hodgkin lymphoma, non-Hodgkin lymphoma and chronic lymphocytic leukaemia were the diagnoses in 81 (25.8%), 203 (64.7%) and 30 (9.6%) patients, respectively. Anaemia was present in 134 patients (42.4%). Anaemia of chronic disease was present in 33/46 (71.7%) and iron deficiency in 18/46 (39.1%) patients. Vitamin B12 and/or folate deficiency was detected in 10/46 (21.7%) patients (B12 deficiency alone in 7, folate deficiency alone in 1 and combined B12 and folate deficiency in 2). Autoimmune haemolytic anaemia was detected in 5/46 (10.9%) although direct Coombs test was positive in 17/46 (37%) patients. Among patients with Hodgkin lymphoma and non-Hodgkin lymphoma, anaemia due to bone marrow involvement was present in 16/40 (40%). In most patients with bone marrow involvement, anaemia was due to other causes. In only 3 patients, anaemia was attributable to bone marrow involvement alone. Anaemia was multifactorial in 18/46 (39.1%) patients. Nutritional deficiency alone or in combination was present in 22/46 (47.8%) patients. Conclusion. Anaemia is common in lymphoid malignancies at initial presentation. Besides managing anaemia of chronic disease and bone marrow involvement, nutritional and autoimmune causes should be ruled out.en_US
dc.identifier.citationGHOSH J, BIKRAMJIT SINGH R K, SAXENA R, GUPTA R, VIVEKANANDAN S, SREENIVAS V, RAINA V, SHARMA A, KUMAR L. Prevalence and aetiology of anaemia in lymphoid malignancies. National Medical Journal of India. 2013 Mar-Apr ; 26 (2): 79-81.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156336
dc.language.isoenen_US
dc.source.urihttps://nmji.in/archives/Volume-26/Issue-2/Short-Report.pdfen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnemia --epidemiology
dc.subject.meshAnemia --etiology
dc.subject.meshAnemia, Hemolytic, Autoimmune --epidemiology
dc.subject.meshAnemia, Hemolytic, Autoimmune --etiology
dc.subject.meshAnemia, Iron-Deficiency --epidemiology
dc.subject.meshAnemia, Iron-Deficiency--etiology
dc.subject.meshBone Marrow --pathology
dc.subject.meshFemale
dc.subject.meshFolic Acid Deficiency --complications
dc.subject.meshHodgkin Disease --complications
dc.subject.meshHumans
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell --complications
dc.subject.meshLymphoma, Non-Hodgkin --complications
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPrevalence
dc.subject.meshProspective Studies
dc.subject.meshVitamin B 12 Deficiency --complications
dc.subject.meshYoung Adult
dc.titlePrevalence and aetiology of anaemia in lymphoid malignancies.en_US
dc.typeArticleen_US
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