Biliary sepsis: an ascending infection.

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dc.contributor.authorBapat, R Den_US
dc.contributor.authorSupe, A Nen_US
dc.contributor.authorPatwardhan, Aen_US
dc.contributor.authorKocher, H Men_US
dc.contributor.authorParab, Sen_US
dc.contributor.authorSathe, M Jen_US
dc.date.accessioned1996-10-01en_US
dc.date.accessioned2009-05-29T02:16:43Z
dc.date.available1996-10-01en_US
dc.date.available2009-05-29T02:16:43Z
dc.date.issued1996-10-01en_US
dc.description.abstractAIM: To study the bacteriology of normal and obstructed biliary tree and determine the mode of biliary infection. METHODS: Fifty seven patients undergoing elective biliary surgery for calculous biliary disease cholecystitis 45, obstructive jaundice 12) were studied. Bile samples collected separately from gall bladder, common bile duct and duodenum at the time of surgery were processed for aerobic and anaerobic cultures and antibiotic assays. To locate endogenous foci of infection, urine, nasal swab and throat swab cultures were done. Isolates from/biliary tract were compared with those from other sites. RESULTS: Thirty eight patients (66.7%) had bactobilia. The prevalence was higher in patients with obstructive jaundice (10/12, 83.3%) than (p = 0.5) in those with non-obstructed biliary tree. Single bacterial infection (31 cases, 81 %) was more common than mixed infection (7 cases, 19%). Colonization of more than one segment of the biliary tree was seen in 30 patients (79%). E coli was the most frequently isolated organism. In 24 cases (63.2%), strains of organisms from the common bile duct and gall bladder were similar to those from the duodenum, and in only 10 cases (23.2%) were similar to those found in the nose, throat and urine. The antibiotic concentrations in the common bile duct after single doses of preoperative antibiotic (gentamicin and cephazolin) were lower in the obstructed biliary tree (1.5 +/- 0.4 milligrams/mL and 2.8 milligrams/mL respectively) than in the non-obstructed system (3.9 +/- 1.7 milligrams and 12.6 milligrams/mL/mL respectively) (p = 0.5 for both antibiotics). CONCLUSION: Ascending infection forms the mode of biliary sepsis in a majority of cases. Prophylactic antibiotics give low levels in the bile in an obstructed biliary tree.en_US
dc.description.affiliationDepartment of Gastroenterology Surgery, Seth G S Medical College, Mumbai.en_US
dc.identifier.citationBapat RD, Supe AN, Patwardhan A, Kocher HM, Parab S, Sathe MJ. Biliary sepsis: an ascending infection. Indian Journal of Gastroenterology. 1996 Oct; 15(4): 126-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63947
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Bacterial Agents --analysisen_US
dc.subject.meshBacteria --isolation & purificationen_US
dc.subject.meshBacterial Infections --etiologyen_US
dc.subject.meshBile --chemistryen_US
dc.subject.meshBiliary Tract Diseases --microbiologyen_US
dc.subject.meshBiliary Tract Surgical Procedures --adverse effectsen_US
dc.subject.meshCholecystitis --surgeryen_US
dc.subject.meshCholestasis, Extrahepatic --surgeryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshSepsis --etiologyen_US
dc.titleBiliary sepsis: an ascending infection.en_US
dc.typeJournal Articleen_US
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