Vernal keratoconjunctivitis in human immunodeficiency virus – The possible role of T-helper 1–T-helper 2 shift

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dc.contributor.authorAgarwal, Sen_US
dc.contributor.authorSrinivasan, Ben_US
dc.contributor.authorIyer, Gen_US
dc.contributor.authorSudharshan, Sen_US
dc.contributor.authorKalaivani, Ken_US
dc.date.accessioned2020-04-10T01:59:47Z
dc.date.available2020-04-10T01:59:47Z
dc.date.issued2018-07
dc.description.abstractHuman immunodeficiency virus infection (HIV) is associated with a reduced T-helper (Th) 1 response, and vernal keratoconjunctivitis (VKC) occurs secondary to a heightened Th2 response. VKC has been reported to occur in patients with HIV. In all probability, a Th1–Th2 shift occurs in the immune response in progressive HIV patients with a decreasing CD4 count. This shift could be the probable cause for the initiation and gradual worsening of the VKC in our patient that corresponded to the dropping CD4 counts. VKC resolved only after a change in antiretroviral therapy for HIV that caused a demonstrable increase in the CD4 counts possibly by reversing the shift.en_US
dc.identifier.affiliationsCJ Shah Cornea Services/Dr G Sitalakshmi Memorial Clinic For Ocular Surface Disorders, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Uvea, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatric Ophthalmology and Strabismus, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationAgarwal S, Srinivasan B, Iyer G, Sudharshan S, Kalaivani K. Vernal keratoconjunctivitis in human immunodeficiency virus – The possible role of T-helper 1–T-helper 2 shift. Indian Journal of Ophthalmology. 2018 Jul; 66(7): 1004-1006en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196789
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber7en_US
dc.relation.volume66en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_76_18en_US
dc.subjectAllergic conjunctivitisen_US
dc.subjecthuman immunodeficiency virusen_US
dc.subjectvernal keratoconjunctivitisen_US
dc.titleVernal keratoconjunctivitis in human immunodeficiency virus – The possible role of T-helper 1–T-helper 2 shiften_US
dc.typeJournal Articleen_US
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