Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital.

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dc.contributor.authorAssanasen, Thamathornen_US
dc.contributor.authorWannakrairot, Pongsaken_US
dc.contributor.authorKeelawat, Somboonen_US
dc.contributor.authorRuangvejvorachai, Preechaen_US
dc.contributor.authorPramprayoon, Nootchanaten_US
dc.date.accessioned2009-05-27T18:41:47Z
dc.date.available2009-05-27T18:41:47Z
dc.date.issued2005-09-21en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: High frequency of Epstein-Barr virus (EBV) in the normal mucosa of the upper aerodigestive tract suggests that it may serve as a reservoir for the virus. Malignant lymphomas arising in this site may be associated with EBV. OBJECTIVES: To determine the prevalence of EBV infection in extranodal malignant lymphomas of the upper aerodigestive tract. SETTING: King Chulalongkorn Memorial Hospital, Thailand. DESIGN: Descriptive study. PATIENTS: 42 Thai patients who presented between 1998 and 2003. MATERIAL AND METHOD: The expression of EBV mRNAs (EBERs) of malignant lymphoma was studied by means of in situ hybridization in formalin-fixed, paraffin-embedded specimens. RESULTS: The recruited subjects were 26 males and 16 females, and their age ranged from 3 to 85 years with the mean of 51.43 years, in 4 of them human immune deficiency virus (HIV) infection was documented. Ten of 42 cases (23.81%) expressed EBER transcripts and were extranodal NK/T-cell lymphomas, nasal type (7 cases), plasmablastic lymphomas (2 cases) and diffuse large B-cell lymphoma (1 case). Three of 4 cases (75%) of known HIV-seropositive cases were EBV-positive (2 plasmablastic lymphomas and 1 diffuse large B-cell lymphoma). CONCLUSION: In the upper aerodigestive tract, EBV was present in some but not all malignant lymphoma. It was associated with extranodal NK/T-cell lymphoma, nasal type and B-cell lymphoma arising in HIV-infected patients, but it was not found in B-cell lymphoma arising in immunocompetent patients.en_US
dc.description.affiliationDepartment of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Thamathorn.A@chula.ac.then_US
dc.identifier.citationAssanasen T, Wannakrairot P, Keelawat S, Ruangvejvorachai P, Pramprayoon N. Extranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital. Journal of the Medical Association of Thailand. 2005 Sep; 88 Suppl 4(): S266-73en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/39664
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDisease Reservoirsen_US
dc.subject.meshEpstein-Barr Virus Infections --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human --isolation & purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshLymphoma --physiopathologyen_US
dc.subject.meshLymphoma, B-Cell --physiopathologyen_US
dc.subject.meshLymphoma, T-Cell --physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRespiratory System --physiopathologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThailand --epidemiologyen_US
dc.subject.meshUpper Gastrointestinal Tract --physiopathologyen_US
dc.titleExtranodal malignant lymphoma of the upper aerodigestive tract: prevalence of Epstien-Barr virus (EBV) infection in King Chulalongkorn Memorial Hospital.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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