Derivation of leukemic plasmacytoid dendritic cells coexpressing a progenitor cell surface antigen, CD117, without interferon-alpha production.

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dc.contributor.authorTakeda, Tomohiroen_US
dc.contributor.authorHayashida, Masahikoen_US
dc.contributor.authorKadowaki, Norimitsuen_US
dc.contributor.authorTakeoka, Kayoen_US
dc.contributor.authorFukuda, Miekoen_US
dc.contributor.authorSakurai, Yoshihikoen_US
dc.date.accessioned2009-05-27T17:27:37Z
dc.date.available2009-05-27T17:27:37Z
dc.date.issued2007-03-26en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractCD4+CD56+ lineage negative malignancy has recently been considered as plasmacytoid dendritic cell (PDC) leukemia/lymphoma. We investigated immunophenotypic and functional characterizations of PDC leukemic cells in one case. Lineage markers were all negative except partially positive CD11c and positive CD117, indicating malignant cells were leukemic PDCs coexpressing myeloid and progenitor cell surface antigens. Leukemic PDCs cultured with IL-3 increased in size and expression of CD11c, CD40 and HLA-DR, although the cells cultured with IL-2 or GM-CSF showed little proliferation. Furthermore, CD40 ligation after IL-3 stimulation yielded morphological changes such as expression of dendritic process. These findings showed that malignant cells were consistent with leukemic PDCs. However, secretion of interferon-alpha was not detected in leukemic PDCs with the stimulation of CpG ODN or inactivated herpes simplex virus-1.en_US
dc.description.affiliationClinical Laboratory, Uda General Hospital, Uda, Japan.en_US
dc.identifier.citationTakeda T, Hayashida M, Kadowaki N, Takeoka K, Fukuda M, Sakurai Y. Derivation of leukemic plasmacytoid dendritic cells coexpressing a progenitor cell surface antigen, CD117, without interferon-alpha production. Asian Pacific Journal of Allergy and Immunology. 2007 Mar; 25(1): 91-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37240
dc.language.isoengen_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, CD --analysisen_US
dc.subject.meshCell Lineageen_US
dc.subject.meshDendritic Cells --immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshInterferon-alpha --secretionen_US
dc.subject.meshLeukemia --immunologyen_US
dc.subject.meshLymphokines --immunologyen_US
dc.titleDerivation of leukemic plasmacytoid dendritic cells coexpressing a progenitor cell surface antigen, CD117, without interferon-alpha production.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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