Resolution of Primary Aortic Thrombosis after Dabigatran therapy—A New Hope for the Rare and Old Disease

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dc.contributor.authorJariwala, Pankajen_US
dc.contributor.authorKale, Satya Sridharen_US
dc.date.accessioned2020-01-02T06:40:28Z
dc.date.available2020-01-02T06:40:28Z
dc.date.issued2019-03
dc.description.abstractThe primary aortic thrombosis (PAT) is an uncommon noncardiac cause of distal peripheral embolization to lower extremities. Also, this condition develops in the absence of extensive atherosclerosis of aorta or abnormal dilatation like aneurysm of the aorta. In most of the cases, there was either no or minimal atherosclerosis of the aorta. The disease can involve any part of the aorta, but in most of the cases, the thoracic aorta below the origin of the left subclavian artery followed by the infrarenal portion of the abdominal aorta was the most common site of involvement. In our case, there was extensive thrombosis starting from the lower part of the thoracic aorta extending across both the renal arteries up to the aortic bifurcation without any underlying aortic pathology or hypercoagulable disease. There are no guidelines for the management of the PAT, but our experience is based on few case series, case reports, and meta-analysis where there are variable success rate using conservative medical management, endovascular procedure, or surgical thrombectomy. Vitamin K antagonist was the drug of choice in all the cases as a part of conservative medical management or used to prevent recurrence after the endovascular or surgical procedure. We present a case of PAT where the use of dabigatran leads to complete resolution and prevented the recurrence of the disease during two-year follow-up, which is the first and unique case report of the literature.en_US
dc.identifier.affiliationsDepartment of Cardiology and Cardio-thoracic Surgery, Yashoda Hospitals, Raj Bhavan Road, Somajiguda, Hyderabad, Telangana, 500082, Indiaen_US
dc.identifier.citationJariwala Pankaj, Kale Satya Sridhar. Resolution of Primary Aortic Thrombosis after Dabigatran therapy—A New Hope for the Rare and Old Disease. Indian Heart Journal. 2019 Mar; 71(2): 166-169en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/191717
dc.languageenen_US
dc.publisherCardiological Society of Indiaen_US
dc.relation.issuenumber2en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2019.03.005en_US
dc.subjectPrimary aortic thrombosisen_US
dc.subjectDirect oral anticoagulanten_US
dc.subjectVitamin K antagonisten_US
dc.subjectDabigatranen_US
dc.titleResolution of Primary Aortic Thrombosis after Dabigatran therapy—A New Hope for the Rare and Old Diseaseen_US
dc.typeJournal Articleen_US
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