High-altitude pulmonary oedema: Newer treatment modalities for an age-old problem

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dc.contributor.authorYanamandra, Uen_US
dc.contributor.authorSharma, Men_US
dc.contributor.authorKatoch, Den_US
dc.contributor.authorYanamandra, Sen_US
dc.contributor.authorBhattachar, SAen_US
dc.contributor.authorGupta, Aen_US
dc.contributor.authorPatyal, Sen_US
dc.contributor.authorGrewal, Ren_US
dc.contributor.authorKumar, Sen_US
dc.contributor.authorNair, Ven_US
dc.date.accessioned2020-04-10T01:42:53Z
dc.date.available2020-04-10T01:42:53Z
dc.date.issued2019-06
dc.description.abstractBackground & objectives: High-altitude pulmonary oedema (HAPE) continues to challenge the healthcare providers at remote, resource-constrained settings. High-altitude terrain itself precludes convenience of resources. This study was conducted to evaluate the rise in peripheral capillary saturation of oxygen (SpO2) by the use of a partial rebreathing mask (PRM) in comparison to Hudson's mask among patients with HAPE. Methods: This was a single-centre, randomized crossover study to determine the efficiency of PRM in comparison to Hudson's mask. A total of 88 patients with HAPE referred to a secondary healthcare facility at an altitude of 11,500 feet from January to October 2013 were studied. A crossover after adequate wash-out on both modalities was conducted for first two days of hospital admission. All patients with HAPE were managed with bed rest and stand-alone oxygen supplementation with no adjuvant pharmacotherapy. Results: The mean SpO2on ambient air on arrival was 66.92�.8 per cent for all patients with HAPE. Higher SpO2values were achieved with PRM in comparison to Hudson's mask on day one (86.08�15 vs. 77.23�09%) and day two (89.94�96 vs. 83.39�93%). The difference was more pronounced on day one as compared to day two. Interpretation & conclusions: Mean SpO2values were found to be significantly higher among HAPE patients using PRM compared to those on Hudson's mask. Further studies to understand the translation of this incremental response in SpO2to clinical benefits (recovery times, mortality rates and hospital stay) need to be undertaken.en_US
dc.identifier.affiliationsDepartment of Medicine, High Altitude Medical Research Centre, Leh, Ladakh, Indiaen_US
dc.identifier.affiliationsMilitary Nursing Services, Integrated HQ, Ministry of Defence, New Delhi, Indiaen_US
dc.identifier.affiliationsStation Medicare Centre, Air Force Station, Vadodara, Indiaen_US
dc.identifier.affiliationsDepartment of Physiology, High Altitude Medical Research Centre, Leh, Ladakh, Indiaen_US
dc.identifier.affiliationsDepartment of Radiology, High Altitude Medical Research Centre, Leh, Ladakh, Indiaen_US
dc.identifier.affiliationsDepartment of 153 General Hospital, High Altitude Medical Research Centre, Leh, Ladakh, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, Army Research & Referral Hospital, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, Armed Forces Medical College, Pune, Indiaen_US
dc.identifier.citationYanamandra U, Sharma M, Katoch D, Yanamandra S, Bhattachar SA, Gupta A, Patyal S, Grewal R, Kumar S, Nair V. High-altitude pulmonary oedema: Newer treatment modalities for an age-old problem. Indian Journal of Medical Research. 2019 Jun; 149(6): 778-782en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195900
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber6en_US
dc.relation.volume149en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_1981_17en_US
dc.subjectEnvironmental illnessen_US
dc.subjecthigh-altitude pulmonary oedemaen_US
dc.subjectoccupational healthen_US
dc.subjectoxygen delivery systemsen_US
dc.subjectoxygen therapyen_US
dc.titleHigh-altitude pulmonary oedema: Newer treatment modalities for an age-old problemen_US
dc.typeJournal Articleen_US
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