Effects of Nigella sativa supplementation for one month on cardiac reserve in rats.

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dc.contributor.authorYar, Ten_US
dc.contributor.authorEl-Hariri, Men_US
dc.contributor.authorEl-Bahai, M Nen_US
dc.contributor.authorBamosa, A Oen_US
dc.date.accessioned2008-04-10en_US
dc.date.accessioned2009-06-01T08:07:29Z
dc.date.available2008-04-10en_US
dc.date.available2009-06-01T08:07:29Z
dc.date.issued2008-04-10en_US
dc.description.abstractNigella sativa (N. sativa) has a long history of use in folk medicine. In a current study performed in this laboratory, two-month dietary supplementation with N. sativa extract to normal rats has shown a homogenous cardiac hypertrophy and enhanced cardiac contractility at baseline conditions. In the present study, shorter (one-month) duration of oral N. sativa administration was adopted to detect possible earlier cardiac responses. In addition, in vitro cardiac stress by the beta adrenoceptor agonist isoproterenol was used to assess the intrinsic cardiac reserve mechanisms. The hearts of Nigella-treated rats developed a moderate but significant hypertrophy that was evident by an increase in the heart weight to body weight ratio. The observed Nigella-induced cardiac hypertrophy was associated with an increase in the baseline cardiac inotropic properties as well as the maximal peak tension generation upon progressive cardiac stress by isoproterenol infusion. The demonstrated selective enhancement of the inotropic reserve favours the physiological nature of Nigella-induced cardiac hypertrophy, similar to that provoked by exercise training.en_US
dc.description.affiliationDepartment of Physiology, College of Medicine, King Faisal University, PO Box 2114, Dammam 31451, Kingdom of Saudi Arabia.en_US
dc.identifier.citationYar T, El-Hariri M, El-Bahai MN, Bamosa AO. Effects of Nigella sativa supplementation for one month on cardiac reserve in rats. Indian Journal of Physiology and Pharmacology. 2008 Apr-Jun; 52(2): 141-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108676
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdaptation, Physiologicalen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdrenergic beta-Agonists --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiomegaly --chemically induceden_US
dc.subject.meshCardiotonic Agents --pharmacologyen_US
dc.subject.meshDietary Supplementsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshIsoproterenol --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Contraction --drug effectsen_US
dc.subject.meshNigella sativaen_US
dc.subject.meshPerfusionen_US
dc.subject.meshPlant Extracts --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVentricular Pressure --drug effectsen_US
dc.titleEffects of Nigella sativa supplementation for one month on cardiac reserve in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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