Comparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, India

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dc.contributor.authorChakraborty, Sen_US
dc.contributor.authorPrasad, Gen_US
dc.contributor.authorMarwaha, RKen_US
dc.contributor.authorBasu, Aen_US
dc.contributor.authorTandon, Nen_US
dc.contributor.authorBharadwaj, Den_US
dc.date.accessioned2020-04-10T01:45:14Z
dc.date.available2020-04-10T01:45:14Z
dc.date.issued2020-01
dc.description.abstractBackground & objectives: Obesity-mediated chronic inflammatory state is primarily governed by lifestyle and food habits in adolescents and marked by alterations in the level of various inflammatory markers. This cross-sectional study was aimed to compare the inflammatory status of healthy Indian adolescents vis-�-vis their obesity profile. The inflammatory state of urban adolescents attending private and government-funded schools, and the relationship between inflammatory marker levels and anthropometric indices in the study participants from both groups were examined. Methods: A total of 4438 study participants (10-17 yr) were chosen from various schools of Delhi, India, and their anthropometric parameters were measured. Plasma adipocytokines (adiponectin, leptin and resistin) of the study participants were measured by enzyme-linked immunosorbent assay, and plasma C-reactive protein (CRP) levels were assayed by a biochemical analyzer. Metabolic syndrome-related risk factors such as waist circumference, hip circumference (HC), fasting glucose, fasting insulin, Homeostatic Model Assessment of Insulin Resistance, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and triglycerides of normal-weight adolescents were also evaluated. Results: The level of leptin and CRP increased with increasing adiposity, whereas adiponectin levels were found to be negatively related to obesity. All plasma cytokine levels (adiponectin, leptin and resistin) were significantly elevated in female than male adolescents. Age-based classification revealed a distinct trend of variability in the levels of all the inflammatory markers among adolescents of varying age groups. Significant differences were observed between private and government schoolgoing adolescents in terms of anthropometric and inflammatory parameters, with higher adiposity indices in the former group. The relationship of plasma adipokine and CRP levels with various adiposity indices was found to be distinctly different between private and government schoolgoing students. Interpretation & conclusions: Inflammatory markers were significantly elevated in overweight/obese adolescents. The socio-economic condition of urban Indian schoolgoing adolescents reflecting lifestyle transition has profound effects on their adiposity indices and inflammatory states. Longitudinal studies in different regions of the country need to be done to further confirm the findings.en_US
dc.identifier.affiliationsGenomics & Molecular Medicine Unit, CSIR-Institute of Genomics & Integrative Biology; Academy of Scientific & Innovative Research, CSIR-Institute of Genomics & Integrative Biology South Campus, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrinology, International Life Sciences Institute, New Delhi, Indiaen_US
dc.identifier.affiliationsStatistical & Computational Genomics, National Institute of Biomedical Genomics, Kalyani, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrinology & Metabolism, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsAcademy of Scientific & Innovative Research, CSIR-Institute of Genomics & Integrative Biology South Campus; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, Indiaen_US
dc.identifier.citationChakraborty S, Prasad G, Marwaha RK, Basu A, Tandon N, Bharadwaj D. Comparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, India. Indian Journal of Medical Research. 2020 Jan; 151(1): 47-58en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196128
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber1en_US
dc.relation.volume151en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_1631_18en_US
dc.subjectAdipocytokinesen_US
dc.subjectCRPen_US
dc.subjectIndian adolescentsen_US
dc.subjectinflammatory markersen_US
dc.subjectjuvenile healthen_US
dc.subjectlifestyle changesen_US
dc.subjectobesityen_US
dc.subjectsocio-economic statusen_US
dc.titleComparison of plasma adipocytokines & C-reactive protein levels in healthy schoolgoing adolescents from private & government-funded schools of Delhi, Indiaen_US
dc.typeJournal Articleen_US
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