Development of a controlled release formulation of an indigenous insect growth regulator, DPE-28, a substituted diphenylether, for controlling the breeding of Culex quinquefasciatus.

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dc.contributor.authorKalyanasundaram, M
dc.contributor.authorMathew, Nisha
dc.contributor.authorElango, A
dc.contributor.authorPadmanabhan, V
dc.date.accessioned2011-12-07T04:39:17Z
dc.date.available2011-12-07T04:39:17Z
dc.date.issued2011-06
dc.description.abstractBackground & objectives: DPE-28, a substituted diphenyl ether (2,6-ditertiarybutyl phenyl-2’,4’-dinitro phenyl ether) was reported to exhibit promising insect growth regulating activity against Culex quinquefasciatus, the vector of lymphatic filariasis. A controlled release formulation (CRF) of DPE-28 has been developed to control Cx. quinquefasciatus in its breeding habitats. Toxicity of DPE-28, safety to non-target mosquito predators and the release profile of the CRF of DPE-28 are studied and discussed. Methods: The acute oral and dermal toxicity was tested in male and female Wistar rats as per the Organization for Economic Cooperation and Development (OECD) guidelines 425 and 402 respectively. The toxicity of DPE-28 to non-target predators was tested as per the reported procedure from this laboratory. The CRF of DPE-28 was prepared by following the reported procedure developed at this laboratory earlier. The concentration of DPE-28 released from the CRF was monitored by HPLC by constructing a calibration graph by plotting the peak area in the Y-axis and the concentration of DPE-28 in the X-axis. Results: DPE-28 has been tested for acute oral toxicity and found to be moderately toxic with LD50 value of 1098 mg/kg body weight (b.w). The results of the acute dermal toxicity and skin irritation studies reveal that DPE-28 is safe and non-irritant. DPE-28 when tested at 0.4 mg/litre against non-target mosquito predators did not produce any mortality. The release profile of the active ingredient DPE-28 from the CRF by HPLC technique showed that the average daily release (ADR) of DPE-28 ranged from 0.07 to 5.0 mg/litre during first four weeks. Thereafter the matrix started eroding and the ADR ranged from 5 to 11 mg/litre during the remaining 5 wk. The cumulative release of active ingredient showed that > 90 per cent of the active ingredient was released from the matrix. Interpretation & conclusions: The controlled release matrix of DPE-28 was thus found to inhibit the adult emergence (>80%) of Cx. quinquefasciatus for a period of nine weeks. The CRF of DPE-28 may play a useful role in field and may be recommended for mosquito control programme after evaluating the same under field conditions.en_US
dc.identifier.citationKalyanasundaram M, Mathew Nisha, Elango A, Padmanabhan V. Development of a controlled release formulation of an indigenous insect growth regulator, DPE-28, a substituted diphenylether, for controlling the breeding of Culex quinquefasciatus. Indian Journal of Medical Research. 2011 June; 133(6): 650-654.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135710
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135994/en_US
dc.subjectControlled release formulationen_US
dc.subjectdiphenyletheren_US
dc.subjectDPE-28en_US
dc.subjectinsect growth regulatoren_US
dc.subjectmosquito larval controlen_US
dc.subject.meshAnimals
dc.subject.meshBreeding
dc.subject.meshCulex --drug effects
dc.subject.meshCulex --physiology
dc.subject.meshDelayed-Action Preparations --chemistry
dc.subject.meshDelayed-Action Preparations --toxicity
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInsect Vectors
dc.subject.meshInsecticides --administration & dosage
dc.subject.meshInsecticides --chemistry
dc.subject.meshInsecticides --pharmacology
dc.subject.meshInsecticides --toxicity
dc.subject.meshJuvenile Hormones --administration & dosage
dc.subject.meshJuvenile Hormones --chemistry
dc.subject.meshJuvenile Hormones --pharmacology
dc.subject.meshJuvenile Hormones --toxicity
dc.subject.meshLarva --drug effects
dc.subject.meshLethal Dose 50
dc.subject.meshMale
dc.subject.meshMosquito Control --methods
dc.subject.meshPhenyl Ethers --administration & dosage
dc.subject.meshPhenyl Ethers --chemistry
dc.subject.meshPhenyl Ethers --pharmacology
dc.subject.meshPhenyl Ethers --toxicity
dc.subject.meshRabbits
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.titleDevelopment of a controlled release formulation of an indigenous insect growth regulator, DPE-28, a substituted diphenylether, for controlling the breeding of Culex quinquefasciatus.en_US
dc.typeArticleen_US
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