Functional status of auditory pathways in hypothyroidism: evoked potential study.

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dc.contributor.authorAnjana, Yumnamen_US
dc.contributor.authorVaney, Neelamen_US
dc.contributor.authorTandon, O Pen_US
dc.contributor.authorMadhu, S Ven_US
dc.date.accessioned2006-10-04en_US
dc.date.accessioned2009-06-01T06:24:03Z
dc.date.available2006-10-04en_US
dc.date.available2009-06-01T06:24:03Z
dc.date.issued2006-10-04en_US
dc.description.abstractHypothyroidism is known to be associated with mental retardation, motor dysfunction, memory deficits and hearing impairment. In the present study, the functional integrity of the thalamocortical projections to the primary auditory cortex and association cortex has been assessed by using Auditory Evoked Responses i.e Auditory Brainstem (ABR), Mid Latency Response (MLR) and Slow Vertex Response (SVR). Thirty newly diagnosed hypothyroid patients and thirty healthy controls were taken for the study and ABR, MLR and SVR were recorded on computerized evoked potential recorder using 10-20 system of electrode placement. The second recordings for the hypothyroid patients were done 3 months after treatment with attainment of euthyroid states. The present study revealed a slight increase in absolute latency of wave III of ABR in hypothyroid patients and significant decrease in absolute latency of wave III and interpeak latency of I-III after treatment. There was a significant decrease in amplitude of wave V in hypothyroid patients and significant increase in amplitudes of ABR wave I and wave V after treatment. There was a significant increase in latency of wave Na of MLR and wave P2 of SVR in hypothyroid patients. The latencies of waves Na, Pa, Nb of MLR and waves PI and N2 of SVR showed significant improvement with thyroid hormone treatment. The results of the present study indicates that in hypothyroid state there might be slow conduction at the periphery and with treatment there is better recruitment of neuronal pool of the generators of the waves of ABR in the brainstem. We can also conclude that the thalamocortical projections of the auditory pathways are adversely affected in the hypothyroid state and this improves after treatment.en_US
dc.description.affiliationDepartment of Physiology, University College Of Medical Sciences and G.T.B. Hospital, Dilshad Garden, Delhi. anjana_y@rediffmail.comen_US
dc.identifier.citationAnjana Y, Vaney N, Tandon OP, Madhu SV. Functional status of auditory pathways in hypothyroidism: evoked potential study. Indian Journal of Physiology and Pharmacology. 2006 Oct-Dec; 50(4): 341-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107357
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcoustic Stimulationen_US
dc.subject.meshAdulten_US
dc.subject.meshAuditory Cortex --physiologyen_US
dc.subject.meshAuditory Pathways --physiopathologyen_US
dc.subject.meshEvoked Potentials, Auditory --physiologyen_US
dc.subject.meshEvoked Potentials, Auditory, Brain Stem --physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism --physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshThalamus --physiologyen_US
dc.titleFunctional status of auditory pathways in hypothyroidism: evoked potential study.en_US
dc.typeJournal Articleen_US
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