Evaluation of Vitamin D Status in Children with Nephrotic Syndrome in Remission in a Tertiary Care Hospital of North India
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Date
2020-04
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Publisher
JK Science
Abstract
Childhood nephrotic syndrome (NS) is characterized by massive proteinuria, hypoalbuminemia, hyperlipidemiaassociated with peripheral edema. Children with NS lose 25-OH vitamin D binding protein in urine, and canhave low blood levels of this metabolite. The present hospital-based study was carried out on a total of 50children with nephrotic syndrome who are in remission, in the age group of 1-15 years of either gender,attending to our pediatric nephrology clinic. 46% had clear deficiency of vitamin D, while insufficiency waspresent in 28% and normal levels in only 26% of patients. There was significant difference (p<0.05) in 25-OHvitamin D levels between frequent relapsers (FR) as compared to infrequent relapsers (IR) and first episode ofnephrotic syndrome. Hypocalcemia was present in 86% of patients, hypophosphatemia in 10% of patients,hyperphosphatemia in 50% and raised alkaline phosphatase in 36% of patients. Strong positive correlation isobserved between serum calcium and vitamin D levels (r=0.720; p<0.001) and moderate negative correlationbetween phosphorous and vitamin D levels (r= -0.577; p<0.001, but insignificant relation between vitamin Dand alkaline phosphate levels (r= -0.248; p<0.082). It is concluded that vitamin D deficiency is commonamong children with nephrotic syndrome even after remission of proteinuria. There exists a strong positivecorrelation between serum calcium and vitamin D levels.
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Keywords
Nephrotic Syndrome, Vitamin D, Serum Calcium, Phosphorus, Alkaline Phosphate
Citation
Badyal Ashima, Kumar Koushal. Evaluation of Vitamin D Status in Children with Nephrotic Syndrome in Remission in a Tertiary Care Hospital of North India. JK Science Journal of Medical Education and Research. 2020 Apr; 2020 Apr: 92-95