A clinicopathological study of granulosa cell tumors of the ovary: Can morphology predict prognosis?

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dc.contributor.authorGuleria, Pen_US
dc.contributor.authorKumar, Len_US
dc.contributor.authorKumar, Sen_US
dc.contributor.authorBhatla, Nen_US
dc.contributor.authorRay, Ren_US
dc.contributor.authorSinghal, Sen_US
dc.contributor.authorMeena, Jen_US
dc.contributor.authorMathur, SRen_US
dc.date.accessioned2020-04-10T01:51:01Z
dc.date.available2020-04-10T01:51:01Z
dc.date.issued2020-03
dc.description.abstractObjective: Granulosa cell tumors (GCT) are low-grade malignant sex cord-stromal tumors (SCST) with late metastasis/recurrences and long disease-free periods. We performed a clinicopathological evaluation of GCT to ascertain features having prognostic impact. Materials and Methods: All cases of GCT of ovary from January 2006 to December 2018 were assessed for architectural patterns, nuclear grooves, and Call-Exner bodies. Each feature was graded on frequency of occurrence: not present (0)–very frequent (3). Anisonucleosis, necrosis, and inflammation were noted. Cases were grouped on mitotic count; <10 mitosis/10 High power field (HPF) or >=11 mitoses/10 HPF and Ki-67 index; <10% Ki-67 and >=11% Ki-67. Results: GCT formed 60.1% of SCST. Sixty cases' ages were in the range of 15–78 years (median 45). Clinical details were available in 37. Commonest presentation was abnormal uterine bleeding. Serum CA125 was raised in 16.1% and Inhibin in 58.8%. Seventy percent were in stage I. Disease recurrence was associated with higher stage (P = 0.007). The most frequent pattern was diffuse sheets (47%). Call-Exner bodies were absent in 22.2%. Grooves with score 1, 2, and 3 were seen in 35.8%, 23.5%, and 13.6%, respectively. Anisonucleosis was present in 26.7%, necrosis in 11.1%, and lympho-plasmacytic infiltrate in 43%. Out of total, 93.3% had <10 mitosis/10 HPF and 43.2% had recurrence, most with high Ki-67 (P = 0.064). Conclusion: Our study outlines histomorphological spectrum of GCT and emphasizes its frequent occurrence in lower stages with late recurrences. The presence of grooves may indicate granulosa-cell origin. Call-Exner bodies are not a necessity. Histomorphological features are not prognostically important. However, prognostic value of Ki-67 cannot be excluded. Limitation of the study was a small number of cases with follow-up.en_US
dc.identifier.affiliationsDepartment of Pathology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Oncology, Dr. BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationGuleria P, Kumar L, Kumar S, Bhatla N, Ray R, Singhal S, Meena J, Mathur SR. A clinicopathological study of granulosa cell tumors of the ovary: Can morphology predict prognosis?. Indian Journal of Pathology and Microbiology. 2020 Mar; 63(1): 53-59en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196424
dc.languageenen_US
dc.publisherIndian Association of Pathologists and Microbiologistsen_US
dc.relation.issuenumber1en_US
dc.relation.volume63en_US
dc.source.urihttps://dx.doi.org/10.4103/IJPM.IJPM_403_19en_US
dc.subjectClinicopathological correlationen_US
dc.subjectgranulosa cell tumor ovaryen_US
dc.subjecthistopathological featuresen_US
dc.subjectKi-67 proliferation indexen_US
dc.subjectprognostic factorsen_US
dc.titleA clinicopathological study of granulosa cell tumors of the ovary: Can morphology predict prognosis?en_US
dc.typeJournal Articleen_US
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