Prevalence and clinical relevance of serum anti-p53 antibodies in patients with cholangiocarcinoma.

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dc.contributor.authorTangkijvanich, Pen_US
dc.contributor.authorKasemsupatana, Ken_US
dc.contributor.authorJanchai, Aen_US
dc.contributor.authorKullavanijaya, Pen_US
dc.contributor.authorTheamboonlers, Aen_US
dc.contributor.authorPoovorawan, Yen_US
dc.date.accessioned2009-05-27T17:19:49Z
dc.date.available2009-05-27T17:19:49Z
dc.date.issued2000-09-29en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractCholangiocarcinoma (CCA) constitutes carcinoma of the bile duct found at a high prevalence in northeastern Thailand. In the present study, we examined the sera of altogether 82 Thai CCA patients for the presence of anti-p53 antibodies in order to investigate a role of the tumor suppressor gene, p53 in the carcinogenesis. Our results revealed anti-p53 antibodies in 7.3% of the cases tested, which conforms to the prevalence rate of p53 gene mutation recently reported at 5% among Thai patients. With limited number of the patients, anti-p53 antibodies were rapidly detected more frequently among patients with peripheral tumors than those with central tumors. However, further studies is required to establish significance and prognostic value of the antibodies in the context of CCA.en_US
dc.description.affiliationDepartment of Biochemistry, Faculty of Medicine Chulalongkorn University & Hospital, Bangkok, Thailand.en_US
dc.identifier.citationTangkijvanich P, Kasemsupatana K, Janchai A, Kullavanijaya P, Theamboonlers A, Poovorawan Y. Prevalence and clinical relevance of serum anti-p53 antibodies in patients with cholangiocarcinoma. Asian Pacific Journal of Allergy and Immunology. 2000 Sep; 18(3): 173-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36955
dc.language.isoengen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshAntibodies, Antinuclear --blooden_US
dc.subject.meshAntibodies, Neoplasm --blooden_US
dc.subject.meshBile Duct Neoplasms --geneticsen_US
dc.subject.meshBile Ducts, Intrahepaticen_US
dc.subject.meshCholangiocarcinoma --geneticsen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, p53en_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSerum Albumin --metabolismen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshTumor Suppressor Protein p53 --geneticsen_US
dc.subject.meshalpha-Fetoproteins --metabolismen_US
dc.titlePrevalence and clinical relevance of serum anti-p53 antibodies in patients with cholangiocarcinoma.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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