Age related toxic effects of endosulfan on certain enzymes of rat erythrocytes.

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dc.contributor.authorKiran, Ren_US
dc.contributor.authorVarma, M Nen_US
dc.date.accessioned2009-05-28T12:04:36Z
dc.date.available2009-05-28T12:04:36Z
dc.date.issued1990-07-01en_US
dc.description.abstractThe effect of oral administration of endosulfan (12.5 mg/kg body weight), daily for 4 days was investigated on erythrocytes of female rats of 4 different age groups i.e. 15, 30, 70 and 365 days old. Erythrocyte membrane Na+, K(+)-ATPase and Mg2(+)-ATPase activities were significantly inhibited in all the age groups of rats. However, percent inhibition was maximum in the youngest animals. A significant decrease in the activity of erythrocyte glutathione reductase was observed in 30 and 70 days old rats whereas a significant increase in the activity of glucose-6-phosphate dehydrogenase (G-6-PD) was observed in these groups. The increase in G-6-PD activity may be a physiological response to compensate for decrease in the reduced glutathione level which results from decrease in the activity of glutathione reductase.en_US
dc.description.affiliationDepartment of Biochemistry, Panjab University, Chandigarh, India.en_US
dc.identifier.citationKiran R, Varma MN. Age related toxic effects of endosulfan on certain enzymes of rat erythrocytes. Indian Journal of Experimental Biology. 1990 Jul; 28(7): 694-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57591
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAging --blooden_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Membrane Permeability --drug effectsen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshEndosulfan --pharmacologyen_US
dc.subject.meshErythrocytes --drug effectsen_US
dc.subject.meshGlutathione --blooden_US
dc.subject.meshRatsen_US
dc.titleAge related toxic effects of endosulfan on certain enzymes of rat erythrocytes.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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