Chelation therapy and vanadium: effect on reproductive organs in rats.

Simple item page
dc.contributor.authorShrivastava, Sadhanaen_US
dc.contributor.authorJadon, Anjanaen_US
dc.contributor.authorShukla, Sangeetaen_US
dc.contributor.authorMathur, Rameshen_US
dc.date.accessioned2009-05-28T13:06:53Z
dc.date.available2009-05-28T13:06:53Z
dc.date.issued2007-06-26en_US
dc.description.abstractPresent investigation was planned to evaluate the therapeutic effectiveness of chelating agents against vanadium intoxication on blood and reproductive organs of rats. Male and female albino rats were injected vanadyl sulphate (7.5 mg/kg, po, for 21 days, 5 days in a week). Chelating agents tiron (T) alone and in combination with lipoic acid (LA), vitamin E (vit E) and selenium (Se) were given for 2 days/week. With the administration of vanadyl sulphate to rats fructose level in seminal vesicles was significantly (P< or =0.05) declined. The activities of alkaline phosphatase and adenosine triphosphatase were also decreased, whereas glycogen content and acid phosphatase activity increased in testis, seminal vesicles, ovaries and uterus after toxicant exposure. Significant changes in serum transaminases, serum alkaline phosphatase and lactate dehydrogenase were recouped by chelation therapy. Lipid peroxidation, reduced glutathione level and triglycerides levels altered significantly after exposure to vanadium in rats. The ultrastructural damage in spermatogenic stages in treated animals showed recovery pattern after therapy. Co-treatment with antioxidants restored these activities. The most effective combination was tiron + selenium followed by tiron + vitamin E, and tiron + lipoic acid.en_US
dc.description.affiliationReproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior 474 011, India. dr_sadhana59@rediffmail.comen_US
dc.identifier.citationShrivastava S, Jadon A, Shukla S, Mathur R. Chelation therapy and vanadium: effect on reproductive organs in rats. Indian Journal of Experimental Biology. 2007 Jun; 45(6): 515-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58981
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5272/1/IJEB%2045%286%29%20515-523.pdfen_US
dc.subject.mesh1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt --administration & dosageen_US
dc.subject.meshAdenosine Triphosphatases --metabolismen_US
dc.subject.meshAlkaline Phosphatase --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshChelating Agents --therapeutic useen_US
dc.subject.meshChelation Therapyen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlycogen --metabolismen_US
dc.subject.meshGonads --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSelenium --administration & dosageen_US
dc.subject.meshThioctic Acid --administration & dosageen_US
dc.subject.meshVanadium --toxicityen_US
dc.subject.meshVitamin E --administration & dosageen_US
dc.titleChelation therapy and vanadium: effect on reproductive organs in rats.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology