Role of KATP channels in reduced antinociceptive effect of morphine in streptozotocin-induced diabetic mice.

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dc.contributor.authorSood, Ven_US
dc.contributor.authorSharma, Aen_US
dc.contributor.authorSingh, Men_US
dc.date.accessioned2009-05-28T12:55:48Z
dc.date.available2009-05-28T12:55:48Z
dc.date.issued2000-05-29en_US
dc.description.abstractThe nociceptive effect was measured using withdrawal latency in tail flick test in mice rendered diabetic by administering streptozotocin (200 mg/kg, i.p.). The antinociceptive effect of morphine (4 and 8 mg/kg, s.c.) and cromakalim, a KATP channel opener, (0.3, 1 and 2 micrograms, i.c.v.) was significantly reduced in diabetic mice. Moreover, co-administration of cromakalim(0.3 microgram) did not alter the reduced antinociceptive effect of morphine(4 mg/kg) in diabetic mice. Spleenectomy in diabetic mice restored the decrease in antinociceptive effect of morphine and cromakalim. Multiple dose treatment with insulin to maintain euglycaemia for 3 days in diabetic mice prevented the decrease in antinociceptive effect of morphine and cromakalim. However, hyperglycaemic tyrode's buffer did not alter the pD2 value of morphine in isolated guinea pig ileum suggesting that hyperglycaemia does not interfere with mu receptor mediated responses in vitro. The results suggest that hyperglycaemia induced decrease in antinociceptive effect of morphine and cromakalim may be due to alteration in KATP channels. Some unknown factor from spleen in diabetic mice may be responsible for this alteration in KATP channels in diabetic mice.en_US
dc.description.affiliationDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.en_US
dc.identifier.citationSood V, Sharma A, Singh M. Role of KATP channels in reduced antinociceptive effect of morphine in streptozotocin-induced diabetic mice. Indian Journal of Experimental Biology. 2000 May; 38(5): 447-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58738
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdenosine Triphosphate --metabolismen_US
dc.subject.meshAnalgesics --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCromakalim --pharmacologyen_US
dc.subject.meshDiabetes Mellitus, Experimental --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIleum --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMorphine --pharmacologyen_US
dc.subject.meshPotassium Channels --metabolismen_US
dc.subject.meshSpleen --physiopathologyen_US
dc.titleRole of KATP channels in reduced antinociceptive effect of morphine in streptozotocin-induced diabetic mice.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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