Lymphocyte and NK cell subpopulations in HIV seronegative Thais.

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dc.contributor.authorAssawawitoontip, Sujinen_US
dc.contributor.authorPuthavathana, Pilaipanen_US
dc.contributor.authorPattanapanyasat, Koviten_US
dc.contributor.authorSukpanichnant, Sathienen_US
dc.contributor.authorThammataksin, Sauwalaken_US
dc.contributor.authorHonda, Mitsuoen_US
dc.contributor.authorWarachit, Paijiten_US
dc.date.accessioned2009-05-27T17:23:25Z
dc.date.available2009-05-27T17:23:25Z
dc.date.issued2003-06-25en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractLymphocyte subpopulations, i.e. T, B and natural killer (NK) cells including NK cell subsets which express CD16 molecules (with or without co-expression of CD56 molecules) and NK cell subsets which express CD56 molecules (with or without co-expression of CD16 molecules) were enumerated by two color-flow cytometry in a total of 125 HIV seronegative Thai adults. The study demonstrated relatively low CD4 counts in the subjects, i.e. 26.3% of them had a CD4 count of less than 500 cells/microl. In contrast, their NK cell counts were relatively high. Statistical analyses of the percentage values showed that females had significantly higher CD3 (total T cells), but lower NK cell counts as compared to males (p < 0.05). Regarding age variation, an increase of 1.1% of CD4 cells per decade was seen. It was roughly estimated that about 86% of NK cells harbored both CD16 and CD56 molecules. Collective data from several studies including the present one suggest that high NK cell counts may be a compensation for low CD4 cell counts in Mongoloid people. Thus, the role of NK cells in the defense cascade against viral infections, especially human immunodeficiency virus infections deserves further investigation.en_US
dc.description.affiliationDepartment of Microbiology, Mahidol University, Thailand.en_US
dc.identifier.citationAssawawitoontip S, Puthavathana P, Pattanapanyasat K, Sukpanichnant S, Thammataksin S, Honda M, Warachit P. Lymphocyte and NK cell subpopulations in HIV seronegative Thais. Asian Pacific Journal of Allergy and Immunology. 2003 Jun; 21(2): 95-103en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37086
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Differentiation, T-Lymphocyte --biosynthesisen_US
dc.subject.meshCD4 Lymphocyte Counten_US
dc.subject.meshCell Differentiation --immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHIV Seronegativity --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKiller Cells, Natural --cytologyen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshLymphocyte Subsets --cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshT-Lymphocytes --cytologyen_US
dc.subject.meshThailand --epidemiologyen_US
dc.titleLymphocyte and NK cell subpopulations in HIV seronegative Thais.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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