Antineutrophil cytoplasmic antibody (ANCA) and rapidly progressive crescentic glomerulonephritis in Thai population.

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dc.contributor.authorSumethkul, Ven_US
dc.contributor.authorChangsirikulchai, Sen_US
dc.contributor.authorRadinahamed, Pen_US
dc.contributor.authorChalermsanyakorn, Pen_US
dc.date.accessioned2009-05-27T17:06:41Z
dc.date.available2009-05-27T17:06:41Z
dc.date.issued1999-12-04en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractThe impact of vasculitis as a cause of primary rapidly progressive crescentic glomerulonephritis (RPGN) was examined in patients with Thai ethnic by antineutrophil cytoplasmic antibody (ANCA) test. Thirty patients found in a six years study period were included. Patients' mean age was 34.8+/-16.4 years. Mean crescent score was 86.2+/-22.9%. ANCA proved positive in fifteen patients. This helps to differentiate vasculitis associated (ANCA positive) from nonvasculitis (ANCA negative) RPGN. Incidence of immune complex type RPGN (46.6%) is higher than the Caucasians while the incidence of antiglomerular basement membrane antibody (anti-GBM disease) is much lower. More vasculitis patients were treated with cyclophosphamide (n = 11) than the nonvasculitis group (n = 2). Mean renal survival time of ANCA and non-ANCA associated patients were 26.69 and 14.16 months, respectively. Renal survival of all patients is significantly worse if associated with a high entry creatinine (>6 mg/dl). Our results show that vasculitis associated RPGN is not an uncommon disease in the Thai population and can be recognized initially by ANCA test.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationSumethkul V, Changsirikulchai S, Radinahamed P, Chalermsanyakorn P. Antineutrophil cytoplasmic antibody (ANCA) and rapidly progressive crescentic glomerulonephritis in Thai population. Asian Pacific Journal of Allergy and Immunology. 1999 Dec; 17(4): 281-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36475
dc.language.isoengen_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Antineutrophil Cytoplasmic --analysisen_US
dc.subject.meshCyclophosphamide --therapeutic useen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Technique, Indirecten_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGlomerulonephritis --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshThailanden_US
dc.subject.meshVasculitis --immunologyen_US
dc.titleAntineutrophil cytoplasmic antibody (ANCA) and rapidly progressive crescentic glomerulonephritis in Thai population.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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