Insulin like growth factors axis and growth disorders.

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dc.contributor.authorBajpai, Anuragen_US
dc.contributor.authorMenon, P S Nen_US
dc.date.accessioned2006-01-31en_US
dc.date.accessioned2009-05-30T10:12:37Z
dc.date.available2006-01-31en_US
dc.date.available2009-05-30T10:12:37Z
dc.date.issued2006-01-31en_US
dc.description27 references.en_US
dc.description.abstractThe growth hormone-insulin like growth factor (GH-IGF) axis plays a crucial role in the regulation of growth. Initially considered to be a mediator of growth hormone actions, IGF axis has been established as an independent endocrine system with wide array of actions. Recent advances have led to tremendous increase in the clinical utility of the IGF axis. IGF-based investigations (IGF1 and IGF binding protein 3) are now replacing GH-based investigations for evaluation and monitoring of disorders of the GH-IGF axis. IGF therapy has been successfully utilized in growth hormone insensitivity syndrome and GHD type 1B. The possibility of IGF axis as therapeutic options is being explored in wide variety of disorders like hypoxic-ischemic encephalopathy, Alzheimer's disease and psoriasis.en_US
dc.description.affiliationDepartment of Endocrinology and Diabetes, Center for Hormone Research, Royal Children's Hospital, Melbourne, Victoria, Australia.en_US
dc.identifier.citationBajpai A, Menon PS. Insulin like growth factors axis and growth disorders. Indian Journal of Pediatrics. 2006 Jan; 73(1): 67-71en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/78409
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshBody Height --physiologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild Development --physiologyen_US
dc.subject.meshGrowth Disorders --physiopathologyen_US
dc.subject.meshGrowth Hormone --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothalamo-Hypophyseal System --physiologyen_US
dc.subject.meshSomatomedins --physiologyen_US
dc.titleInsulin like growth factors axis and growth disorders.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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